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The Protective Role of Interleukin 17A in Acinetobacter baumannii Pneumonia Is Associated with Candida albicans in the Airway.
Tang, Jiaxin; Li, Jiamin; Pan, Jinqing; Shen, Xiaoyuan; Ye, Xiangsheng; Zhou, Jiamin; Wang, Ni; Xie, Liang; Fuchs, Beth Burgwyn; Lionakis, Michail S; Mylonakis, Eleftherios; Tan, Xiaojiang.
Afiliación
  • Tang J; Department of Respiratory and Critical Care Medicine, Chronic Airways Diseases Laboratory, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Li J; Department of Respiratory and Critical Care Medicine, Chronic Airways Diseases Laboratory, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Pan J; Department of Respiratory and Critical Care Medicine, Chronic Airways Diseases Laboratory, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Shen X; Department of Respiratory and Critical Care Medicine, Chronic Airways Diseases Laboratory, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Ye X; Department of Respiratory and Critical Care Medicine, Chronic Airways Diseases Laboratory, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Zhou J; Department of Respiratory and Critical Care Medicine, Chronic Airways Diseases Laboratory, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Wang N; Department of Respiratory and Critical Care Medicine, Chronic Airways Diseases Laboratory, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Xie L; Department of Respiratory and Critical Care Medicine, Chronic Airways Diseases Laboratory, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Fuchs BB; Department of Medicine, Division of Infectious Diseases, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
  • Lionakis MS; Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Mylonakis E; Department of Medicine, Division of Infectious Diseases, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
  • Tan X; Department of Respiratory and Critical Care Medicine, Chronic Airways Diseases Laboratory, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Infect Immun ; 91(1): e0037822, 2023 01 24.
Article en En | MEDLINE | ID: mdl-36602381
Recent studies have found that the coexistence of fungi and bacteria in the airway may increase the risk of infection, contribute to the development of pneumonia, and increase the severity of disease. Interleukin 17A (IL-17A) plays important roles in host resistance to bacterial and fungal infections. The objective of this study was to determine the effects of IL-17A on Acinetobacter baumannii-infected rats with a previous Candida albicans airway inoculation. The incidence of A. baumannii pneumonia was higher in rats with C. albicans in the airway than in noninoculated rats, and it decreased when amphotericin B was used to clear C. albicans, which influenced IL-17A levels. IL-17A had a protective effect in A. baumannii pneumonia associated with C. albicans in the airway. Compared with A. baumannii-infected rats with C. albicans in the airway that did not receive IL-17A, recombinant IL-17A (rIL-17A) supplementation decreased the incidence of A. baumannii pneumonia (10/15 versus 5/17; P = 0.013) and the proportion of neutrophils in the lung (84 ± 3.5 versus 74 ± 4.3%; P = 0.033), reduced tissue destruction and inflammation, and decreased levels of myeloperoxidase (MPO) (1.267 ± 0.15 versus 0.233 ± 0.06 U/g; P = 0.0004), reactive oxygen species (ROS) (132,333 ± 7,505 versus 64,667 ± 10,115 AU; P = 0.0007) and lactate dehydrogenase (LDH) (2.736 ± 0.05 versus 2.1816 ± 0.29 U/g; P = 0.0313). In vitro experiments revealed that IL-17A had no significant effect on the direct migration ability and bactericidal capability of neutrophils. However, IL-17A restrained lysis cell death and increased apoptosis of neutrophils (2.9 ± 1.14 versus 7 ± 0.5%; P = 0.0048). Taken together, our results suggest that C. albicans can depress IL-17A levels, which when supplemented may have a regulatory function that limits the accumulation of neutrophils in inflammatory areas, providing inflammatory response homeostasis.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neumonía / Infecciones por Acinetobacter / Neumonía Bacteriana / Acinetobacter baumannii Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Infect Immun Año: 2023 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neumonía / Infecciones por Acinetobacter / Neumonía Bacteriana / Acinetobacter baumannii Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Infect Immun Año: 2023 Tipo del documento: Article País de afiliación: China