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Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia.
Layton, Mark E; Kern, Jeffrey C; Hartingh, Timothy J; Shipe, William D; Raheem, Izzat; Kandebo, Monika; Hayes, Robert P; Huszar, Sarah; Eddins, Donnie; Ma, Bennett; Fuerst, Joy; Wollenberg, Gordon K; Li, Jing; Fritzen, Jeff; McGaughey, Georgia B; Uslaner, Jason M; Smith, Sean M; Coleman, Paul J; Cox, Christopher D.
Afiliación
  • Layton ME; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
  • Kern JC; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
  • Hartingh TJ; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
  • Shipe WD; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
  • Raheem I; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
  • Kandebo M; Neuroscience, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
  • Hayes RP; Structural Chemistry, Merck & Co., Inc., Boston, Massachusetts 02115, United States.
  • Huszar S; In Vivo Pharmacology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
  • Eddins D; In Vivo Pharmacology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
  • Ma B; Pharmacokinetics, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
  • Fuerst J; Discovery Pharmaceutical Sciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
  • Wollenberg GK; Nonclinical Drug Safety, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
  • Li J; Discovery Process Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
  • Fritzen J; Discovery Process Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
  • McGaughey GB; Chemistry Modeling and Informatics, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
  • Uslaner JM; Neuroscience, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
  • Smith SM; Neuroscience, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
  • Coleman PJ; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
  • Cox CD; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
J Med Chem ; 66(2): 1157-1171, 2023 01 26.
Article en En | MEDLINE | ID: mdl-36624931
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inhibidores de Fosfodiesterasa / Esquizofrenia Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inhibidores de Fosfodiesterasa / Esquizofrenia Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos