Targeting the secreted RGDKGE collagen fragment reduces PD­L1 by a proteasome­dependent mechanism and inhibits tumor growth.

Caron, Jennifer M; Han, Xianghua; Lary, Christine W; Sathyanarayana, Pradeep; Remick, Scot C; Ernstoff, Marc S; Herlyn, Meenhard; Brooks, Peter C

Targeting the secreted RGDKGE collagen fragment reduces PDL1 by a proteasomedependent mechanism and inhibits tumor growth.

Caron, Jennifer M; Han, Xianghua; Lary, Christine W; Sathyanarayana, Pradeep; Remick, Scot C; Ernstoff, Marc S; Herlyn, Meenhard; Brooks, Peter C.

Afiliación

Caron JM; MaineHealth Institute for Research, Center for Molecular Medicine, Scarborough, ME 04074, USA.
Han X; MaineHealth Institute for Research, Center for Molecular Medicine, Scarborough, ME 04074, USA.
Lary CW; MaineHealth Institute for Research, Center for Molecular Medicine, Scarborough, ME 04074, USA.
Sathyanarayana P; MaineHealth Institute for Research, Center for Molecular Medicine, Scarborough, ME 04074, USA.
Remick SC; MaineHealth Institute for Research, Center for Molecular Medicine, Scarborough, ME 04074, USA.
Ernstoff MS; Division of Cancer Treatment and Diagnosis, Developmental Therapeutics Program, National Cancer Institute, Bethesda, MD 20892, USA.
Herlyn M; Wistar Institute, Philadelphia, PA 19104, USA.
Brooks PC; MaineHealth Institute for Research, Center for Molecular Medicine, Scarborough, ME 04074, USA.

Oncol Rep ; 49(2)2023 Feb.

Article en En | MEDLINE | ID: mdl-36633146

Asunto(s)

Antígeno B7-H1; Colágeno; Integrinas; Neoplasias; Fragmentos de Péptidos; Complejo de la Endopetidasa Proteasomal; Humanos; Antígeno B7-H1/metabolismo; Colágeno/química; Colágeno/metabolismo; Integrinas/metabolismo; Neoplasias/tratamiento farmacológico; Neoplasias/metabolismo; Complejo de la Endopetidasa Proteasomal/metabolismo; Fragmentos de Péptidos/metabolismo; Proteínas Señalizadoras YAP/metabolismo; Proteínas Quinasas Dependientes de AMP Cíclico/metabolismo

Palabras clave

YAP; collagen; extracellular matrix; integrin αvß3; programmed deathligand 1; protein kinaseA; stroma

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Integrinas / Colágeno / Complejo de la Endopetidasa Proteasomal / Antígeno B7-H1 / Neoplasias Límite: Humans Idioma: En Revista: Oncol Rep Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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