"THE MANTLE" bundle for minimizing cerebral hypoxia in severe traumatic brain injury.
Crit Care
; 27(1): 13, 2023 01 12.
Article
en En
| MEDLINE
| ID: mdl-36635711
ABSTRACT
To ensure neuronal survival after severe traumatic brain injury, oxygen supply is essential. Cerebral tissue oxygenation represents the balance between oxygen supply and consumption, largely reflecting the adequacy of cerebral perfusion. Multiple physiological parameters determine the oxygen delivered to the brain, including blood pressure, hemoglobin level, systemic oxygenation, microcirculation and many factors are involved in the delivery of oxygen to its final recipient, through the respiratory chain. Brain tissue hypoxia occurs when the supply of oxygen is not adequate or when for some reasons it cannot be used at the cellular level. The causes of hypoxia are variable and can be analyzed pathophysiologically following "the oxygen route." The current trend is precision medicine, individualized and therapeutically directed to the pathophysiology of specific brain damage; however, this requires the availability of multimodal monitoring. For this purpose, we developed the acronym "THE MANTLE," a bundle of therapeutical interventions, which covers and protects the brain, optimizing the components of the oxygen transport system from ambient air to the mitochondria.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Hipoxia Encefálica
/
Lesiones Traumáticas del Encéfalo
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
Crit Care
Año:
2023
Tipo del documento:
Article
País de afiliación:
Argentina