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Loss of epigenetic information as a cause of mammalian aging.
Yang, Jae-Hyun; Hayano, Motoshi; Griffin, Patrick T; Amorim, João A; Bonkowski, Michael S; Apostolides, John K; Salfati, Elias L; Blanchette, Marco; Munding, Elizabeth M; Bhakta, Mital; Chew, Yap Ching; Guo, Wei; Yang, Xiaojing; Maybury-Lewis, Sun; Tian, Xiao; Ross, Jaime M; Coppotelli, Giuseppe; Meer, Margarita V; Rogers-Hammond, Ryan; Vera, Daniel L; Lu, Yuancheng Ryan; Pippin, Jeffrey W; Creswell, Michael L; Dou, Zhixun; Xu, Caiyue; Mitchell, Sarah J; Das, Abhirup; O'Connell, Brendan L; Thakur, Sachin; Kane, Alice E; Su, Qiao; Mohri, Yasuaki; Nishimura, Emi K; Schaevitz, Laura; Garg, Neha; Balta, Ana-Maria; Rego, Meghan A; Gregory-Ksander, Meredith; Jakobs, Tatjana C; Zhong, Lei; Wakimoto, Hiroko; El Andari, Jihad; Grimm, Dirk; Mostoslavsky, Raul; Wagers, Amy J; Tsubota, Kazuo; Bonasera, Stephen J; Palmeira, Carlos M; Seidman, Jonathan G; Seidman, Christine E.
Afiliación
  • Yang JH; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA. Electronic address: jae-hyun_yang@hms.harvard.edu.
  • Hayano M; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA; Department of Ophthalmology, Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
  • Griffin PT; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA.
  • Amorim JA; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA; IIIUC-Institute of Interdisciplinary Research, University of Coimbra, Coimbra, Portugal.
  • Bonkowski MS; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA.
  • Apostolides JK; Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA.
  • Salfati EL; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA.
  • Blanchette M; Cantata/Dovetail Genomics, Scotts Valley, CA, USA.
  • Munding EM; Cantata/Dovetail Genomics, Scotts Valley, CA, USA.
  • Bhakta M; Cantata/Dovetail Genomics, Scotts Valley, CA, USA.
  • Chew YC; Zymo Research Corporation, Irvine, CA, USA.
  • Guo W; Zymo Research Corporation, Irvine, CA, USA.
  • Yang X; Zymo Research Corporation, Irvine, CA, USA.
  • Maybury-Lewis S; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA.
  • Tian X; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA.
  • Ross JM; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA.
  • Coppotelli G; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA.
  • Meer MV; Department of Medicine, Brigham and Women's Hospital, HMS, Boston, MA, USA.
  • Rogers-Hammond R; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA.
  • Vera DL; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA.
  • Lu YR; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA.
  • Pippin JW; Division of Nephrology, University of Washington, Seattle, WA, USA.
  • Creswell ML; Division of Nephrology, University of Washington, Seattle, WA, USA; Georgetown University School of Medicine, Washington, DC, USA.
  • Dou Z; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA.
  • Xu C; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA.
  • Mitchell SJ; Experimental Gerontology Section, NIA/NIH, Baltimore, MD, USA.
  • Das A; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA; Department of Pharmacology, UNSW, Sydney, NSW, Australia.
  • O'Connell BL; Department of Biomolecular Engineering, UCSC, Santa Cruz, CA, USA.
  • Thakur S; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA.
  • Kane AE; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA.
  • Su Q; Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA.
  • Mohri Y; Department of Stem Cell Biology, Tokyo Medical and Dental University, Tokyo, Japan.
  • Nishimura EK; Department of Stem Cell Biology, Tokyo Medical and Dental University, Tokyo, Japan.
  • Schaevitz L; Vium, San Mateo, CA, USA.
  • Garg N; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA.
  • Balta AM; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA.
  • Rego MA; Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA.
  • Gregory-Ksander M; Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, HMS, Boston, MA, USA.
  • Jakobs TC; Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, HMS, Boston, MA, USA.
  • Zhong L; The Massachusetts General Hospital Cancer Center, HMS, Boston, MA, USA.
  • Wakimoto H; Department of Genetics, HMS, Boston, MA, USA.
  • El Andari J; Department of Infectious Diseases/Virology, Section Viral Vector Technologies, Medical Faculty, University of Heidelberg, BioQuant, Heidelberg, Germany.
  • Grimm D; Department of Infectious Diseases/Virology, Section Viral Vector Technologies, Medical Faculty, University of Heidelberg, BioQuant, Heidelberg, Germany.
  • Mostoslavsky R; The Massachusetts General Hospital Cancer Center, HMS, Boston, MA, USA.
  • Wagers AJ; Paul F. Glenn Center for Biology of Aging Research, Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA; Joslin Diabetes Center, Boston, MA, USA.
  • Tsubota K; Department of Ophthalmology, Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
  • Bonasera SJ; Division of Geriatrics, University of Nebraska Medical Center, Durham Research Center II, Omaha, NE, USA.
  • Palmeira CM; Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal.
  • Seidman JG; Department of Genetics, HMS, Boston, MA, USA.
  • Seidman CE; Department of Genetics, HMS, Boston, MA, USA.
Cell ; 186(2): 305-326.e27, 2023 01 19.
Article en En | MEDLINE | ID: mdl-36638792
All living things experience an increase in entropy, manifested as a loss of genetic and epigenetic information. In yeast, epigenetic information is lost over time due to the relocalization of chromatin-modifying proteins to DNA breaks, causing cells to lose their identity, a hallmark of yeast aging. Using a system called "ICE" (inducible changes to the epigenome), we find that the act of faithful DNA repair advances aging at physiological, cognitive, and molecular levels, including erosion of the epigenetic landscape, cellular exdifferentiation, senescence, and advancement of the DNA methylation clock, which can be reversed by OSK-mediated rejuvenation. These data are consistent with the information theory of aging, which states that a loss of epigenetic information is a reversible cause of aging.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Envejecimiento / Epigénesis Genética Límite: Animals Idioma: En Revista: Cell Año: 2023 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Envejecimiento / Epigénesis Genética Límite: Animals Idioma: En Revista: Cell Año: 2023 Tipo del documento: Article