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Defining the age-dependent and tissue-specific circadian transcriptome in male mice.
Wolff, Christopher A; Gutierrez-Monreal, Miguel A; Meng, Lingsong; Zhang, Xiping; Douma, Lauren G; Costello, Hannah M; Douglas, Collin M; Ebrahimi, Elnaz; Pham, Ann; Oliveira, Aline C; Fu, Chunhua; Nguyen, Amy; Alava, Bryan R; Hesketh, Stuart J; Morris, Andrew R; Endale, Mehari M; Crislip, G Ryan; Cheng, Kit-Yan; Schroder, Elizabeth A; Delisle, Brian P; Bryant, Andrew J; Gumz, Michelle L; Huo, Zhiguang; Liu, Andrew C; Esser, Karyn A.
Afiliación
  • Wolff CA; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Myology Institute, University of Florida, Gainesville, FL 32610, USA.
  • Gutierrez-Monreal MA; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Myology Institute, University of Florida, Gainesville, FL 32610, USA; Claude D. Pepper Older Americans Independence Center, University of Florida, Gainesville, FL 32610, USA.
  • Meng L; Department of Biostatistics, University of Florida, Gainesville, FL 32610, USA.
  • Zhang X; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Myology Institute, University of Florida, Gainesville, FL 32610, USA.
  • Douma LG; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Department of Biochemistry and
  • Costello HM; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Department of Biochemistry and
  • Douglas CM; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Myology Institute, University of Florida, Gainesville, FL 32610, USA.
  • Ebrahimi E; Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
  • Pham A; Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
  • Oliveira AC; Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
  • Fu C; Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
  • Nguyen A; Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
  • Alava BR; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
  • Hesketh SJ; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Myology Institute, University of Florida, Gainesville, FL 32610, USA.
  • Morris AR; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
  • Endale MM; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
  • Crislip GR; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
  • Cheng KY; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
  • Schroder EA; Internal Medicine, Pulmonary, University of Kentucky, Lexington, KY 40506, USA; Department of Physiology, University of Kentucky, Lexington, KY 40506, USA.
  • Delisle BP; Department of Physiology, University of Kentucky, Lexington, KY 40506, USA.
  • Bryant AJ; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32610, USA.
  • Gumz ML; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Department of Biochemistry and
  • Huo Z; Department of Biostatistics, University of Florida, Gainesville, FL 32610, USA. Electronic address: zhuo@ufl.edu.
  • Liu AC; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA. Electronic address: andrew.liu@ufl.edu.
  • Esser KA; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Myology Institute, University of Florida, Gainesville, FL 32610, USA; Claude D. Pepper Older Americans Independence Center, University of Florida, Gainesville, FL 32610, USA. Electronic addres
Cell Rep ; 42(1): 111982, 2023 01 31.
Article en En | MEDLINE | ID: mdl-36640301
Cellular circadian clocks direct a daily transcriptional program that supports homeostasis and resilience. Emerging evidence has demonstrated age-associated changes in circadian functions. To define age-dependent changes at the systems level, we profile the circadian transcriptome in the hypothalamus, lung, heart, kidney, skeletal muscle, and adrenal gland in three age groups. We find age-dependent and tissue-specific clock output changes. Aging reduces the number of rhythmically expressed genes (REGs), indicative of weakened circadian control. REGs are enriched for the hallmarks of aging, adding another dimension to our understanding of aging. Analyzing differential gene expression within a tissue at four different times of day identifies distinct clusters of differentially expressed genes (DEGs). Increased variability of gene expression across the day is a common feature of aged tissues. This analysis extends the landscape for understanding aging and highlights the impact of aging on circadian clock function and temporal changes in gene expression.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Relojes Circadianos / Transcriptoma Límite: Animals Idioma: En Revista: Cell Rep Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Relojes Circadianos / Transcriptoma Límite: Animals Idioma: En Revista: Cell Rep Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos