Genetically engineered human pituitary corticotroph tumor organoids exhibit divergent responses to glucocorticoid receptor modulators.

Mallick, Saptarshi; Chakrabarti, Jayati; Eschbacher, Jennifer; Moraitis, Andreas G; Greenstein, Andrew E; Churko, Jared; Pond, Kelvin W; Livolsi, Antonia; Thorne, Curtis A; Little, Andrew S; Yuen, Kevin C J; Zavros, Yana

Mallick, Saptarshi; Chakrabarti, Jayati; Eschbacher, Jennifer; Moraitis, Andreas G; Greenstein, Andrew E; Churko, Jared; Pond, Kelvin W; Livolsi, Antonia; Thorne, Curtis A; Little, Andrew S; Yuen, Kevin C J; Zavros, Yana.

Afiliación

Mallick S; Department of Cellular and Molecular Medicine, University of Arizona College of Medicine, Tucson, Arizona.
Chakrabarti J; Department of Cellular and Molecular Medicine, University of Arizona College of Medicine, Tucson, Arizona.
Eschbacher J; Department of Neuropathology, Barrow Neurological Institute, Phoenix, Arizona.
Moraitis AG; Corcept Therapeutics, Inc, Menlo Park, California.
Greenstein AE; Corcept Therapeutics, Inc, Menlo Park, California.
Churko J; Department of Cellular and Molecular Medicine, University of Arizona College of Medicine, Tucson, Arizona.
Pond KW; Department of Cellular and Molecular Medicine, University of Arizona College of Medicine, Tucson, Arizona.
Livolsi A; MilliporeSigma - Life Science, Rockville, Maryland.
Thorne CA; Department of Cellular and Molecular Medicine, University of Arizona College of Medicine, Tucson, Arizona.
Little AS; Department of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona.
Yuen KCJ; Department of Neuroendocrinology, Barrow Neurological Institute, Phoenix, Arizona.
Zavros Y; Department of Cellular and Molecular Medicine, University of Arizona College of Medicine, Tucson, Arizona. Electronic address: yzavros@arizona.edu.

Transl Res ; 256: 56-72, 2023 06.

Article en En | MEDLINE | ID: mdl-36640905

Asunto(s)

Hipersecreción de la Hormona Adrenocorticotrópica Pituitaria (HACT); Neoplasias Hipofisarias; Humanos; Corticotrofos/metabolismo; Corticotrofos/patología; Receptores de Glucocorticoides/genética; Receptores de Glucocorticoides/metabolismo; Receptores de Glucocorticoides/uso terapéutico; Hipersecreción de la Hormona Adrenocorticotrópica Pituitaria (HACT)/tratamiento farmacológico; Hipersecreción de la Hormona Adrenocorticotrópica Pituitaria (HACT)/metabolismo; Hipersecreción de la Hormona Adrenocorticotrópica Pituitaria (HACT)/patología; Mifepristona/farmacología; Mifepristona/metabolismo; Mifepristona/uso terapéutico; Proteínas Hedgehog; Neoplasias Hipofisarias/tratamiento farmacológico; Neoplasias Hipofisarias/metabolismo; Neoplasias Hipofisarias/patología; Hormona Adrenocorticotrópica/farmacología; Hormona Adrenocorticotrópica/metabolismo; Hormona Adrenocorticotrópica/uso terapéutico

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Hipofisarias / Hipersecreción de la Hormona Adrenocorticotrópica Pituitaria (HACT) Límite: Humans Idioma: En Revista: Transl Res Asunto de la revista: MEDICINA / TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2023 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google