[Potential teratogenicity of modafinil - Conflicting evidence, need for research]. / Tératogénicité potentielle du modafinil des données contradictoires, un besoin de recherche.
Gynecol Obstet Fertil Senol
; 51(3): 186-189, 2023 03.
Article
en Fr
| MEDLINE
| ID: mdl-36642328
ABSTRACT
Central disorders of hypersomnolence include narcolepsy type 1, narcolepsy type 2, idiopathic hypersomnia and hypersomnia associated with medical or mental disorders. Treatment is both non-pharmacological and pharmacological, including wake enhancing drugs and stimulants. One of the first-line treatment (modafinil, MODIODAL®) was the subject of a health authority alert in 2019 concerning a risk of major congenital malformations when taken during organogenesis. Since this date, three epidemiological studies have presented contradictory results. Given their methodological weaknesses, it is not possible at this stage to confirm or deny such a risk for the embryo and its nature if there is one. In clinical practice, because of these uncertainties, it is preferable if possible to suspend the treatment of a pregnant woman during the first 10 weeks from last menstrual period (organogenesis). There is an unmet clinical need for research to clarify the potential teratogenic impact of modafinil.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Hipersomnia Idiopática
/
Estimulantes del Sistema Nervioso Central
/
Trastornos de Somnolencia Excesiva
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Narcolepsia
Tipo de estudio:
Etiology_studies
Límite:
Female
/
Humans
Idioma:
Fr
Revista:
Gynecol Obstet Fertil Senol
Año:
2023
Tipo del documento:
Article