Betulinic acid analogs inhibit N- and T-type voltage-gated calcium channels to attenuate nerve-injury associated neuropathic and formalin models of pain.

Calderon-Rivera, Aida; Gomez, Kimberly; Loya-López, Santiago; Wijeratne, E M Kithsiri; Stratton, Harrison; Tang, Cheng; Duran, Paz; Masterson, Kyleigh; Alsbiei, Omar; Gunatilaka, A A Leslie; Khanna, Rajesh

Calderon-Rivera, Aida; Gomez, Kimberly; Loya-López, Santiago; Wijeratne, E M Kithsiri; Stratton, Harrison; Tang, Cheng; Duran, Paz; Masterson, Kyleigh; Alsbiei, Omar; Gunatilaka, A A Leslie; Khanna, Rajesh.

Afiliación

Calderon-Rivera A; Department of Molecular Pathobiology, College of Dentistry, New York University, New York, NY, United States.
Gomez K; NYU Pain Research Center, New York University, New York, NY, United States.
Loya-López S; Department of Molecular Pathobiology, College of Dentistry, New York University, New York, NY, United States.
Wijeratne EMK; NYU Pain Research Center, New York University, New York, NY, United States.
Stratton H; Department of Molecular Pathobiology, College of Dentistry, New York University, New York, NY, United States.
Tang C; NYU Pain Research Center, New York University, New York, NY, United States.
Duran P; Natural Products Center, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona, Tucson, AZ, United States.
Masterson K; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ, United States.
Alsbiei O; Department of Molecular Pathobiology, College of Dentistry, New York University, New York, NY, United States.
Gunatilaka AAL; NYU Pain Research Center, New York University, New York, NY, United States.
Khanna R; Department of Molecular Pathobiology, College of Dentistry, New York University, New York, NY, United States.

Neurobiol Pain ; 13: 100116, 2023.

Article en En | MEDLINE | ID: mdl-36687466

Palabras clave

Analgesic; BA, Betulinic acid; Betulin analogs; Betulinic acid analogs; CaV2.2, N-type voltage-gated calcium channel; CaV3, T-type voltage-gated calcium channel; DRG, dorsal root ganglia; Formalin model; HVA, high voltage-gated; LVA, low voltage-gated; Pain; SNI, spared nerve injury; Spared nerve injury mode; VGCCs, Voltage-gated calcium channels; Voltage-gated calcium channels

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Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Neurobiol Pain Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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