Association between blood pressure and angiotensin-converting enzymes activity in prepubertal children ∗.
J Hypertens
; 41(4): 545-553, 2023 04 01.
Article
en En
| MEDLINE
| ID: mdl-36723456
ABSTRACT
OBJECTIVES:
Angiotensin-converting enzymes' (ACEs) relationship with blood pressure (BP) during childhood has not been clearly established. We aimed to compare ACE and ACE2 activities between BMI groups in a sample of prepubertal children, and to characterize the association between these enzymes' activities and BP.METHODS:
Cross-sectional study of 313 children aged 8-9âyears old, included in the birth cohort Generation XXI (Portugal). Anthropometric measurements and 24-h ambulatory BP monitoring were performed. ACE and ACE2 activities were quantified by fluorometric methods.RESULTS:
Overweight/obese children demonstrated significantly higher ACE and ACE2 activities, when compared to their normal weight counterparts [median (P25-P75), ACE 39.48 (30.52-48.97) vs. 42.90 (35.62-47.18) vs. 43.38 (33.49-49.89) mU/ml, P for trend = 0.009; ACE2 10.41 (7.58-15.47) vs. 21.56 (13.34-29.09) vs. 29.00 (22.91-34.32) pM/min per ml, P for trend < 0.001, in normal weight, overweight and obese children, respectively]. In girls, night-time systolic BP (SBP) and diastolic BP (DBP) increased across tertiles of ACE activity ( P < 0.001 and P â=â0.002, respectively). ACE2 activity was associated with higher night-time SBP and DBP in overweight/obese girls ( P â=â0.037 and P â=â0.048, respectively) and night-time DBP in the BMI z-score girl adjusted model ( P â=â0.018). Median ACE2 levels were significantly higher among nondipper girls (16.7 vs. 11.6âpM/min per ml, P â=â0.009).CONCLUSIONS:
Our work shows that obesity is associated with activation of the renin-angiotensin-aldosterone system, with significant increase of ACE and ACE2 activities already in childhood. Also, we report sex differences in the association of ACE and ACE2 activities with BP.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Obesidad Infantil
Tipo de estudio:
Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Child
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Female
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Humans
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Male
Idioma:
En
Revista:
J Hypertens
Año:
2023
Tipo del documento:
Article