Observing hydrogen sulfide in the endoplasmic reticulum of cancer cells and zebrafish by using an activity-based fluorescent probe.
Chem Commun (Camb)
; 59(17): 2493-2496, 2023 Feb 23.
Article
en En
| MEDLINE
| ID: mdl-36752717
ABSTRACT
A crucial endogenous signaling chemical, hydrogen sulfide, is involved in many physiological actions. In this work, we created the fluorescent probe ER-Nap-NBD using a naphthalimide fluorophore as the signal reporter, a 7-nitro-1,2,3-benzoxadiazole amine as the responsive moiety, and a sulfonamide part for endoplasmic reticulum targeting. ER-Nap-NBD could be detected the H2S levels in solution and in living systems (cells and zebrafish).
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Sulfuro de Hidrógeno
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2023
Tipo del documento:
Article
País de afiliación:
China