Increase of breathing rate mediated by unilateral optogenetic inactivation of inhibitory neurons in the preBötzinger Complex in vivo.
Respir Physiol Neurobiol
; 311: 104032, 2023 05.
Article
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| MEDLINE
| ID: mdl-36758781
ABSTRACT
Brainstem neural circuits located in the preBötzinger complex (preBötC) and Bötzinger complex (BötC) play a critical role in the control of breathing. In this study, glycinergic preBötC and BötC neurons were inactivated with optogenetics in vivo using mice with Cre inducible expression of eNpHR3.0-EYFP. Unilateral inhibition of glycinergic neurons in the preBötC, and to a lower extend also in the BötC, led to a higher respiratory rate. It can be concluded that functional inactivation of inhibitory neurons leads to a disinhibition of preBötC excitatory neurons and thus an increase in the respiratory drive of the network.
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Banco de datos:
MEDLINE
Asunto principal:
Frecuencia Respiratoria
/
Optogenética
Límite:
Animals
Idioma:
En
Revista:
Respir Physiol Neurobiol
Año:
2023
Tipo del documento:
Article