Distribution of amiodarone and desethylamiodarone in a patient with acute myocardial infarction after intravenous administration.
Clin Cardiol
; 10(11): 674-6, 1987 Nov.
Article
en En
| MEDLINE
| ID: mdl-3677501
ABSTRACT
The autopsy tissues concentration of amiodarone and desethylamiodarone of a man with acute myocardial infarction treated acutely with intravenous amiodarone is reported. Our data indicate that amiodarone is quickly distributed into all highly perfused tissues after intravenous administration with a high amiodarone/desethylamiodarone ratio. We also report here the autopsy case of a woman who died after 30 days of oral therapy with amiodarone. The increase in heart/plasma ratio of amiodarone and desethylamiodarone concentrations and the decrease in amiodarone/desethylamiodarone ratio after one month of therapy could explain the latency in the antiarrhythmic action of the drug.
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Banco de datos:
MEDLINE
Asunto principal:
Amiodarona
/
Infarto del Miocardio
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Cardiol
Año:
1987
Tipo del documento:
Article
País de afiliación:
Italia