A mitochondria-localized iridium(iii) photosensitizer for two-photon photodynamic immunotherapy against melanoma.
Chem Sci
; 14(6): 1461-1471, 2023 Feb 08.
Article
en En
| MEDLINE
| ID: mdl-36794192
ABSTRACT
Conventional photodynamic therapy mainly causes a therapeutic effect on the primary tumor through the localized generation of reactive oxygen species, while metastatic tumors remain poorly affected. Complementary immunotherapy is effective in eliminating small, non-localized tumors distributed across multiple organs. Here, we report the Ir(iii) complex Ir-pbt-Bpa as a highly potent immunogenic cell death inducing photosensitizer for two-photon photodynamic immunotherapy against melanoma. Ir-pbt-Bpa can produce singlet oxygen and superoxide anion radicals upon light irradiation, causing cell death by a combination of ferroptosis and immunogenic cell death. In a mouse model with two physically separated melanoma tumors, although only one of the primary tumors was irradiated, a strong tumor reduction of both tumors was observed. Upon irradiation, Ir-pbt-Bpa not only induced the immune response of CD8+ T cells and the depletion of regulatory T cells, but also caused an increase in the number of the effector memory T cells to achieve long-term anti-tumor immunity.
Texto completo:
1
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Chem Sci
Año:
2023
Tipo del documento:
Article