bioTCIs: Middle-to-Macro Biomolecular Targeted Covalent Inhibitors Possessing Both Semi-Permanent Drug Action and Stringent Target Specificity as Potential Antibody Replacements.

Yang, Jay; Tabuchi, Yudai; Katsuki, Riku; Taki, Masumi

Yang, Jay; Tabuchi, Yudai; Katsuki, Riku; Taki, Masumi.

Afiliación

Yang J; Department of Engineering Science, Graduate School of Informatics and Engineering, University of Electro-Communications (UEC), 1-5-1 Chofugaoka, Chofu 182-8585, Japan.
Tabuchi Y; School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA.
Katsuki R; Department of GI Surgery II, Graduate School of Medicine, Hokkaido University, Sapporo 068-8638, Japan.
Taki M; Department of Engineering Science, Graduate School of Informatics and Engineering, University of Electro-Communications (UEC), 1-5-1 Chofugaoka, Chofu 182-8585, Japan.

Int J Mol Sci ; 24(4)2023 Feb 09.

Article en En | MEDLINE | ID: mdl-36834935

Asunto(s)

Anticuerpos; Diseño de Fármacos; Preparaciones Farmacéuticas; Anticuerpos/química; Anticuerpos/uso terapéutico; Preparaciones Farmacéuticas/química

Palabras clave

covalent aptamer; matchmaking microenvironment; middle-molecule covalent drug; peptide/oligonucleotide therapeutics; pharmacokinetic parameter (kinact/KI); protease/nuclease resistance; quiescent affinity label; reactivity and affinity-based co-selection; reversing adverse drug effects (ADEs); warhead

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Preparaciones Farmacéuticas / Diseño de Fármacos / Anticuerpos Tipo de estudio: Prognostic_studies Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Japón

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google