Comparison of different QT correction methods for nonclinical safety assessment in ketamine-anesthetized Indian rhesus monkeys (<i>Macaca mulatta</i>).

Bhatt, Laxit K; Shah, Chitrang R; Patel, Rajesh J; Patel, Shital D; Patel, Sudhir R; Patel, Vipul A; Patel, Jitendra H; Dwivedi, Pankaj; Shah, Niraj A; Sundar, Rajesh S; Jain, Mukul R

Comparison of different QT correction methods for nonclinical safety assessment in ketamine-anesthetized Indian rhesus monkeys (Macaca mulatta).

Bhatt, Laxit K; Shah, Chitrang R; Patel, Rajesh J; Patel, Shital D; Patel, Sudhir R; Patel, Vipul A; Patel, Jitendra H; Dwivedi, Pankaj; Shah, Niraj A; Sundar, Rajesh S; Jain, Mukul R.

Afiliación

Bhatt LK; Department of Pharmacology and Toxicology, Zydus Research Centre, Zydus Lifesciences Limited, Ahmedabad, India.
Shah CR; Department of Pharmacology and Toxicology, Zydus Research Centre, Zydus Lifesciences Limited, Ahmedabad, India.
Patel RJ; Department of Pharmacology and Toxicology, Zydus Research Centre, Zydus Lifesciences Limited, Ahmedabad, India.
Patel SD; Department of Pharmacology and Toxicology, Zydus Research Centre, Zydus Lifesciences Limited, Ahmedabad, India.
Patel SR; Department of Pharmacology and Toxicology, Zydus Research Centre, Zydus Lifesciences Limited, Ahmedabad, India.
Patel VA; Department of Pharmacology and Toxicology, Zydus Research Centre, Zydus Lifesciences Limited, Ahmedabad, India.
Patel JH; Department of Pharmacology and Toxicology, Zydus Research Centre, Zydus Lifesciences Limited, Ahmedabad, India.
Dwivedi P; Department of Pharmacology and Toxicology, Zydus Research Centre, Zydus Lifesciences Limited, Ahmedabad, India.
Shah NA; Animal Research Facility, Zydus Research Centre, Zydus Lifesciences Limited, Ahmedabad, India.
Sundar RS; Department of Pharmacology and Toxicology, Zydus Research Centre, Zydus Lifesciences Limited, Ahmedabad, India.
Jain MR; Department of Pharmacology and Toxicology, Zydus Research Centre, Zydus Lifesciences Limited, Ahmedabad, India.

Toxicol Mech Methods ; 33(6): 490-501, 2023 Nov.

Article en En | MEDLINE | ID: mdl-36879461

Asunto(s)

Ketamina; Síndrome de QT Prolongado; Animales; Humanos; Electrocardiografía; Macaca mulatta; Ketamina/toxicidad; Frecuencia Cardíaca; Preparaciones Farmacéuticas; Síndrome de QT Prolongado/inducido químicamente

Palabras clave

Cardiovascular safety; QT correction method; QT prolongation; electrocardiography; nonclinical

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Síndrome de QT Prolongado / Ketamina Tipo de estudio: Guideline Límite: Animals / Humans Idioma: En Revista: Toxicol Mech Methods Asunto de la revista: TOXICOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: India

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