Development and evaluation of Hedyotis corymbosa (L.) extract containing phytosomes: a preclinical approach for treatment of neuropathic pain in rodent model.
J Microencapsul
; 40(3): 186-196, 2023 May.
Article
en En
| MEDLINE
| ID: mdl-36880280
ABSTRACT
PURPOSE:
The study was aimed to encapsulate Hedyotis corymbosa extract (HCE) into phytosomes to improve its therapeutic efficacy in neuropathic pain by enhancing the bioavailability of chief chemical constituent Hedycoryside -A (HCA).METHODS:
For preparing phytosomes complexes (F1, F2, and F3), HCE and phospholipids were reacted in disparate ratio. F2 was chosen to assess its therapeutic efficacy in neuropathic pain induced by partial sciatic nerve ligation. Nociceptive threshold and oral bioavailability were also estimated for F2.RESULTS:
Particle size, zeta potential and entrapment efficiency for F2 were analysed as 298.1 ± 1.1 nm, -3.92 ± 0.41 mV and 72.12 ± 0.72% respectively. F2 gave enhanced relative bioavailability (158.92%) of HCA along with a greater neuroprotective potential showing a significant antioxidant effect and augmentation (p < 0.05) in nociceptive threshold with the diminution in damage to nerves.CONCLUSION:
F2 is an optimistic formulation for enhancing the HCE delivery for the effective treatment of neuropathic pain.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Hedyotis
/
Neuralgia
Límite:
Animals
Idioma:
En
Revista:
J Microencapsul
Asunto de la revista:
FARMACIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
India