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Dementia prevention in memory clinics: recommendations from the European task force for brain health services.
Frisoni, Giovanni B; Altomare, Daniele; Ribaldi, Federica; Villain, Nicolas; Brayne, Carol; Mukadam, Naaheed; Abramowicz, Marc; Barkhof, Frederik; Berthier, Marcelo; Bieler-Aeschlimann, Melanie; Blennow, Kaj; Brioschi Guevara, Andrea; Carrera, Emmanuel; Chételat, Gaël; Csajka, Chantal; Demonet, Jean-François; Dodich, Alessandra; Garibotto, Valentina; Georges, Jean; Hurst, Samia; Jessen, Frank; Kivipelto, Miia; Llewellyn, David J; McWhirter, Laura; Milne, Richard; Minguillón, Carolina; Miniussi, Carlo; Molinuevo, José Luis; Nilsson, Peter M; Noyce, Alastair; Ranson, Janice M; Grau-Rivera, Oriol; Schott, Jonathan M; Solomon, Alina; Stephen, Ruth; van der Flier, Wiesje; van Duijn, Cornelia; Vellas, Bruno; Visser, Leonie N C; Cummings, Jeffrey L; Scheltens, Philip; Ritchie, Craig; Dubois, Bruno.
Afiliación
  • Frisoni GB; Memory Center, Department of Rehabilitation and Geriatrics, University Hospitals and University of Geneva Geneva, Switzerland.
  • Altomare D; Memory Center, Department of Rehabilitation and Geriatrics, University Hospitals and University of Geneva Geneva, Switzerland.
  • Ribaldi F; Memory Center, Department of Rehabilitation and Geriatrics, University Hospitals and University of Geneva Geneva, Switzerland.
  • Villain N; Institut de la Mémoire et de la Maladie d'Alzheimer, IM2A, Groupe Hospitalier Pitié-Salpêtrière, Sorbonne Université, Paris, France.
  • Brayne C; Institut du Cerveau et de la Moelle Épinière, UMR-S975, INSERM, Paris, France.
  • Mukadam N; Cambridge Public Health, University of Cambridge, Cambridge, UK.
  • Abramowicz M; Division of Psychiatry, University College London, London, UK.
  • Barkhof F; Genetic Medicine, Diagnostics Dept, University Hospitals and University of Geneva, Geneva, Switzerland.
  • Berthier M; Radiology & Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
  • Bieler-Aeschlimann M; Queen Square Institute of Neurology, University College London, London, UK.
  • Blennow K; Unit of Cognitive Neurology and Aphasia, Centro de Investigaciones Médico-Sanitarias (CIMES), University of Malaga, Malaga, Spain.
  • Brioschi Guevara A; Leenaards Memory Centre, Department of Clinical Neurosciences, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
  • Carrera E; Infections Disease Service, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
  • Chételat G; Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden.
  • Csajka C; Leenaards Memory Centre, Department of Clinical Neurosciences, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
  • Demonet JF; Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland.
  • Dodich A; Stroke Center, Department of Clinical Neurosciences, University Hospitals and University of Geneva, Geneva, Switzerland.
  • Garibotto V; Normandie University, UNICAEN, INSERM, U1237, PhIND Physiopathology and Imaging of Neurological Disorders, Cyceron, Caen, France.
  • Georges J; Center of Research and Innovation in Clinical Pharmaceutical Sciences, University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Hurst S; Leenaards Memory Centre, Department of Clinical Neurosciences, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
  • Jessen F; French Clinical Research Infrastructure Network, INSERM, University Hospital of Toulouse, France.
  • Kivipelto M; Center for Mind/Brain Sciences (CIMeC), University of Trento, Rovereto, Italy.
  • Llewellyn DJ; Division of Nuclear Medicine and Molecular Imaging, University Hospitals of Geneva and NIMTLab, University of Geneva, Geneva, Switzerland.
  • McWhirter L; Alzheimer Europe, Luxembourg.
  • Milne R; Institute for Ethics, History, and the Humanities, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • Minguillón C; Department of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Miniussi C; German Center for Neurodegenerative Diseases (DZNE), Bonn-Cologne, Germany.
  • Molinuevo JL; Excellence Cluster Cellular Stress Responses in Aging-Related Diseases (CECAD), Medical Faculty, University of Cologne, Germany.
  • Nilsson PM; Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
  • Noyce A; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
  • Ranson JM; Theme Aging, Karolinska University Hospital, Stockholm, Sweden.
  • Grau-Rivera O; The Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, UK.
  • Schott JM; College of Medicine and Health, University of Exeter, UK.
  • Solomon A; Alan Turing Institute, Exeter, UK.
  • Stephen R; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Scotland, UK.
  • van der Flier W; Cambridge Public Health, University of Cambridge, Cambridge, UK.
  • van Duijn C; Engagement and Society, Wellcome Connecting Science, Hinxton, UK.
  • Vellas B; Barcelonaßeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.
  • Visser LNC; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
  • Cummings JL; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain.
  • Scheltens P; Center for Mind/Brain Sciences (CIMeC), University of Trento, Rovereto, Italy.
  • Ritchie C; Centre for Medical Sciences (CISMed), University of Trento, Rovereto, Italy.
  • Dubois B; Barcelonaßeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.
Lancet Reg Health Eur ; 26: 100576, 2023 Mar.
Article en En | MEDLINE | ID: mdl-36895446
Observational population studies indicate that prevention of dementia and cognitive decline is being accomplished, possibly as an unintended result of better vascular prevention and healthier lifestyles. Population aging in the coming decades requires deliberate efforts to further decrease its prevalence and societal burden. Increasing evidence supports the efficacy of preventive interventions on persons with intact cognition and high dementia risk. We report recommendations for the deployment of second-generation memory clinics (Brain Health Services) whose mission is evidence-based and ethical dementia prevention in at-risk individuals. The cornerstone interventions consist of (i) assessment of genetic and potentially modifiable risk factors including brain pathology, and risk stratification, (ii) risk communication with ad-hoc protocols, (iii) risk reduction with multi-domain interventions, and (iv) cognitive enhancement with cognitive and physical training. A roadmap is proposed for concept validation and ensuing clinical deployment.
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Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Guideline / Risk_factors_studies Idioma: En Revista: Lancet Reg Health Eur Año: 2023 Tipo del documento: Article País de afiliación: Suiza
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Guideline / Risk_factors_studies Idioma: En Revista: Lancet Reg Health Eur Año: 2023 Tipo del documento: Article País de afiliación: Suiza