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Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration.
Neel, Dylan V; Basu, Himanish; Gunner, Georgia; Bergstresser, Matthew D; Giadone, Richard M; Chung, Haeji; Miao, Rui; Chou, Vicky; Brody, Eliza; Jiang, Xin; Lee, Edward; Watts, Michelle E; Marques, Christine; Held, Aaron; Wainger, Brian; Lagier-Tourenne, Clotilde; Zhang, Yong-Jie; Petrucelli, Leonard; Young-Pearse, Tracy L; Chen-Plotkin, Alice S; Rubin, Lee L; Lieberman, Judy; Chiu, Isaac M.
Afiliación
  • Neel DV; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA.
  • Basu H; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA.
  • Gunner G; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA.
  • Bergstresser MD; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA.
  • Giadone RM; Department of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
  • Chung H; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA.
  • Miao R; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
  • Chou V; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Brody E; Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Jiang X; Department of Neurology, Mass General Institute for Neurodegenerative Disease (MIND), Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Lee E; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Watts ME; Department of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
  • Marques C; Department of Neurology, Sean M. Healey & AMG Center for ALS, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Held A; Department of Neurology, Sean M. Healey & AMG Center for ALS, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Wainger B; Department of Neurology, Sean M. Healey & AMG Center for ALS, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Lagier-Tourenne C; Department of Neurology, Mass General Institute for Neurodegenerative Disease (MIND), Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Broad Institute of Harvard University and MIT, Cambridge, MA 02142, USA.
  • Zhang YJ; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Petrucelli L; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Young-Pearse TL; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Chen-Plotkin AS; Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Rubin LL; Department of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
  • Lieberman J; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: judy.lieberman@childrens.harvard.edu.
  • Chiu IM; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: isaac_chiu@hms.harvard.edu.
Neuron ; 111(8): 1222-1240.e9, 2023 04 19.
Article en En | MEDLINE | ID: mdl-36917977

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Esclerosis Amiotrófica Lateral Límite: Animals / Humans Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Esclerosis Amiotrófica Lateral Límite: Animals / Humans Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos