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Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation.
Bopp, Selina; Pasaje, Charisse Flerida A; Summers, Robert L; Magistrado-Coxen, Pamela; Schindler, Kyra A; Corpas-Lopez, Victoriano; Yeo, Tomas; Mok, Sachel; Dey, Sumanta; Smick, Sebastian; Nasamu, Armiyaw S; Demas, Allison R; Milne, Rachel; Wiedemar, Natalie; Corey, Victoria; Gomez-Lorenzo, Maria De Gracia; Franco, Virginia; Early, Angela M; Lukens, Amanda K; Milner, Danny; Furtado, Jeremy; Gamo, Francisco-Javier; Winzeler, Elizabeth A; Volkman, Sarah K; Duffey, Maëlle; Laleu, Benoît; Fidock, David A; Wyllie, Susan; Niles, Jacquin C; Wirth, Dyann F.
Afiliación
  • Bopp S; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Pasaje CFA; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA.
  • Summers RL; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Magistrado-Coxen P; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Schindler KA; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA.
  • Corpas-Lopez V; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Yeo T; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA.
  • Mok S; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
  • Dey S; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.
  • Smick S; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
  • Nasamu AS; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
  • Demas AR; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
  • Milne R; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Wiedemar N; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Corey V; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Gomez-Lorenzo MG; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Franco V; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA.
  • Early AM; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.
  • Lukens AK; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.
  • Milner D; Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla, CA, USA.
  • Furtado J; Tres Cantos Medicines Research and Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain.
  • Gamo FJ; Tres Cantos Medicines Research and Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain.
  • Winzeler EA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Volkman SK; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA.
  • Duffey M; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Laleu B; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA.
  • Fidock DA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Wyllie S; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA.
  • Niles JC; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Wirth DF; Tres Cantos Medicines Research and Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain.
Nat Commun ; 14(1): 1455, 2023 03 16.
Article en En | MEDLINE | ID: mdl-36927839
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Malaria Falciparum / Antimaláricos Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Malaria Falciparum / Antimaláricos Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos