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PReS-endorsed international childhood lupus T2T task force definition of childhood lupus low disease activity state (cLLDAS).
Smith, E M D; Aggarwal, A; Ainsworth, J; Al-Abadi, E; Avcin, T; Bortey, L; Burnham, J; Ciurtin, C; Hedrich, C M; Kamphuis, S; Lambert, L; Levy, D M; Lewandowski, L; Maxwell, N; Morand, E; Ozen, S; Pain, C E; Ravelli, A; Saad Magalhaes, C; Pilkington, C; Schonenberg-Meinema, D; Scott, C; Tullus, K; Beresford, M W.
Afiliación
  • Smith EMD; Department of Women's & Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK; Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK. Electronic address: esmith8@liverpool.ac.uk.
  • Aggarwal A; Department of Clinical Immunology & Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
  • Ainsworth J; Department of Women's & Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK; Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
  • Al-Abadi E; Department of Paediatric Rheumatology, Birmingham Women's and Children's Hospital NHS Foundation Trust, Birmingham, UK.
  • Avcin T; Department of Allergology, Rheumatology and Clinical Immunology, Children's Hospital, University Medical Center Ljubljana, Slovenia.
  • Bortey L; TARGET Lupus Public Patient Involvement and Engagement Group, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.
  • Burnham J; Department of Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, USA.
  • Ciurtin C; Centre for Adolescent Rheumatology Versus Arthritis, Division of Medicine, University College London, UK.
  • Hedrich CM; Department of Women's & Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK; Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
  • Kamphuis S; Department of Pediatric Rheumatology, Sophia Children's Hospital, Erasmus University Medical Center, Rotterdam, Netherlands.
  • Lambert L; TARGET Lupus Public Patient Involvement and Engagement Group, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.
  • Levy DM; Division of Rheumatology, Department of Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Canada.
  • Lewandowski L; Lupus Genomics and Global Health Disparities Unit, Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Maxwell N; TARGET Lupus Public Patient Involvement and Engagement Group, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.
  • Morand E; Centre for Inflammatory Diseases, Monash University, Melbourne, Australia.
  • Ozen S; Department of Pediatrics, Hacettepe University, Ankara, Turkey.
  • Pain CE; Department of Women's & Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK; Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
  • Ravelli A; Direzione Scientifica, IRCCS Istituto Giannina Gaslini, Genoa, Italy; Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno Infantili (DINOGMI), Università degli Studi di Genova, Genoa, Italy.
  • Saad Magalhaes C; Department of Pediatric Rheumatology, Botucatu Medical School, Sao Paulo State University, Sao Paulo, Brazil.
  • Pilkington C; Department of Paediatric Rheumatology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
  • Schonenberg-Meinema D; Department of Pediatric Immunology, Rheumatology and Infectious diseases, Emma Children's Hospital, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, the Netherlands.
  • Scott C; Clinical Research Centre, Department of Pediatric Rheumatology, University of Cape Town, Cape Town, South Africa.
  • Tullus K; Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
  • Beresford MW; Department of Women's & Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK; Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
Clin Immunol ; 250: 109296, 2023 05.
Article en En | MEDLINE | ID: mdl-36934849
ABSTRACT

OBJECTIVE:

To achieve a consensus-based definition of Low Disease Activity (LDA) for use in cSLE trials.

METHODS:

The International cSLE T2T Task Force, comprising of paediatric rheumatologists/nephrologists, and adult rheumatologists undertook a series of Delphi surveys/consensus meetings to discuss, refine, and vote upon cSLE LDA criteria.

RESULTS:

The Task Force agreed that LDA should be based upon the adult-SLE Lupus Low Disease Activity State definition (LLDAS), with modifications to make it applicable to cSLE (cLLDAS). They agreed upon five cLLDAS criteria (1) SLE Disease Activity Index (SLEDAI)-2 K ≤4, with no activity in major organ systems; (2) no new features of lupus disease activity compared with the last assessment; (3) Physician Global Assessment score of ≤1 (0-3 scale); (4) prednisolone dose of ≤0.15 mg/kg/day, 7.5 mg/day/maximum; while on (5) stable antimalarials, immunosuppressives, and biologics.

CONCLUSIONS:

A cSLE-appropriate definition of cLLDAS has been generated, maintaining alignment with the adult-SLE definition to promote life-course research.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inmunosupresores / Lupus Eritematoso Sistémico Tipo de estudio: Diagnostic_studies / Guideline Límite: Adult / Child / Humans Idioma: En Revista: Clin Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inmunosupresores / Lupus Eritematoso Sistémico Tipo de estudio: Diagnostic_studies / Guideline Límite: Adult / Child / Humans Idioma: En Revista: Clin Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article