Impact of IgG subclass on monoclonal antibody developability.

Cain, Paul; Huang, Lihua; Tang, Yu; Anguiano, Victor; Feng, Yiqing

Cain, Paul; Huang, Lihua; Tang, Yu; Anguiano, Victor; Feng, Yiqing.

Afiliación

Cain P; Biotechnology Discovery Research, Lilly Research Laboratories, Lilly Technology Center North, Indianapolis, IN, USA.
Huang L; Bioproduct Research & Development, Lilly Research Laboratories, Lilly Technology Center North, Indianapolis, IN, USA.
Tang Y; Pharmaceutical Development and Manufacturing, Syndax Pharmaceuticals, Waltham, MA, USA.
Anguiano V; Bioproduct Research & Development, Lilly Research Laboratories, Lilly Technology Center North, Indianapolis, IN, USA.
Feng Y; Biotechnology Discovery Research, Lilly Research Laboratories, Lilly Technology Center North, Indianapolis, IN, USA.

MAbs ; 15(1): 2191302, 2023.

Article en En | MEDLINE | ID: mdl-36945111

Asunto(s)

Anticuerpos Monoclonales; Inmunoglobulina G; Animales; Cricetinae; Células CHO; Cricetulus; Inmunoglobulina G/química; Ensayo de Inmunoadsorción Enzimática

Palabras clave

Aggregates; IgG subclass; Monoclonal antibodies; charge variants; developability; fragments; host cell protein; post-translational modification; productivity; stability

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inmunoglobulina G / Anticuerpos Monoclonales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: MAbs Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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