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Extrachromosomal Amplification of Human Papillomavirus Episomes Is a Mechanism of Cervical Carcinogenesis.
Rossi, Nicole M; Dai, Jieqiong; Xie, Yi; Wangsa, Darawalee; Heselmeyer-Haddad, Kerstin; Lou, Hong; Boland, Joseph F; Yeager, Meredith; Orozco, Roberto; Freites, Enrique Alvirez; Mirabello, Lisa; Gharzouzi, Eduardo; Dean, Michael.
Afiliación
  • Rossi NM; Division of Cancer Epidemiology and Genetics, NCI, NIH, Rockville, Maryland.
  • Dai J; Leidos Biomedical Research, Inc., National Laboratory for Cancer Research, Frederick, Maryland.
  • Xie Y; Division of Cancer Epidemiology and Genetics, NCI, NIH, Rockville, Maryland.
  • Wangsa D; Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Heselmeyer-Haddad K; Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Lou H; Leidos Biomedical Research, Inc., National Laboratory for Cancer Research, Frederick, Maryland.
  • Boland JF; Leidos Biomedical Research, Inc., National Laboratory for Cancer Research, Frederick, Maryland.
  • Yeager M; Leidos Biomedical Research, Inc., National Laboratory for Cancer Research, Frederick, Maryland.
  • Orozco R; Hospital General San Juan de Dios, Guatemala.
  • Freites EA; Hospital Central Universitario "Dr. Antonio M Pineda," Barquisimeto, Lara State, Venezuela, and Universidad Andino de Cusco, Cusco, Perú.
  • Mirabello L; Division of Cancer Epidemiology and Genetics, NCI, NIH, Rockville, Maryland.
  • Gharzouzi E; Integra Cancer Center, Guatemala City, Guatemala.
  • Dean M; Division of Cancer Epidemiology and Genetics, NCI, NIH, Rockville, Maryland.
Cancer Res ; 83(11): 1768-1781, 2023 06 02.
Article en En | MEDLINE | ID: mdl-36971511
ABSTRACT

SIGNIFICANCE:

Multimers of the HPV genome are generated in cervical tumors replicating as extrachromosomal episomes, which is associated with deletion and rearrangement of the HPV genome and provides a mechanism for oncogenesis without integration.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias del Cuello Uterino / Infecciones por Papillomavirus Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Cancer Res Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias del Cuello Uterino / Infecciones por Papillomavirus Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: Cancer Res Año: 2023 Tipo del documento: Article