Time series clustering of T cell subsets dissects heterogeneity in immune reconstitution and clinical outcomes among MUD-HCT patients receiving ATG or PTCy.

Leserer, Saskia; Graf, Theresa; Franke, Martina; Bogdanov, Rashit; Arrieta-Bolaños, Esteban; Buttkereit, Ulrike; Leimkühler, Nils; Fleischhauer, Katharina; Reinhardt, Hans Christian; Beelen, Dietrich W; Turki, Amin T

Leserer, Saskia; Graf, Theresa; Franke, Martina; Bogdanov, Rashit; Arrieta-Bolaños, Esteban; Buttkereit, Ulrike; Leimkühler, Nils; Fleischhauer, Katharina; Reinhardt, Hans Christian; Beelen, Dietrich W; Turki, Amin T.

Afiliación

Leserer S; Department of Hematology and Stem Cell Transplantation, West-German Cancer Center, University Hospital Essen, Essen, Germany.
Graf T; Computational Hematology Lab, Department of Hematology and Stem Cell Transplantation, West-German Cancer Center, University Hospital Essen, Essen, Germany.
Franke M; Institute for Experimental Cellular Therapy, West-German Cancer Center, University Hospital Essen, Essen, Germany.
Bogdanov R; Department of Hematology and Stem Cell Transplantation, West-German Cancer Center, University Hospital Essen, Essen, Germany.
Arrieta-Bolaños E; Computational Hematology Lab, Department of Hematology and Stem Cell Transplantation, West-German Cancer Center, University Hospital Essen, Essen, Germany.
Buttkereit U; Department of Hematology and Stem Cell Transplantation, West-German Cancer Center, University Hospital Essen, Essen, Germany.
Leimkühler N; Department of Hematology and Stem Cell Transplantation, West-German Cancer Center, University Hospital Essen, Essen, Germany.
Fleischhauer K; Computational Hematology Lab, Department of Hematology and Stem Cell Transplantation, West-German Cancer Center, University Hospital Essen, Essen, Germany.
Reinhardt HC; Institute for Experimental Cellular Therapy, West-German Cancer Center, University Hospital Essen, Essen, Germany.
Beelen DW; German Cancer Consortium Deutsches Konsortium für Translationale Krebsforschung (DKTK), Partner site Essen/Düsseldorf, Essen, Germany.
Turki AT; Department of Hematology and Stem Cell Transplantation, West-German Cancer Center, University Hospital Essen, Essen, Germany.

Front Immunol ; 14: 1082727, 2023.

Article en En | MEDLINE | ID: mdl-37020562

Asunto(s)

Enfermedad Injerto contra Huésped; Trasplante de Células Madre Hematopoyéticas; Reconstitución Inmune; Humanos; Factores de Tiempo; Suero Antilinfocítico; Trasplante de Células Madre Hematopoyéticas/efectos adversos; Ciclofosfamida; Subgrupos de Linfocitos T

Palabras clave

GVHD prophylaxis; anti-T-lymphocyte globulin; anti-thymocyte globulin (ATG); dynamic time warping (DTW); matched unrelated donor allogeneic hematopoietic stem cell transplantation; post-transplant cyclophosphamide; time-series (TS) model; unsupervised learning

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trasplante de Células Madre Hematopoyéticas / Reconstitución Inmune / Enfermedad Injerto contra Huésped Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Front Immunol Año: 2023 Tipo del documento: Article País de afiliación: Alemania

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