Accumulation of m6A exhibits stronger correlation with MAPT than ß-amyloid pathology in an APPNL-G-F /MAPTP301S mouse model of Alzheimer's disease.

Jiang, Lulu; Roberts, Rebecca; Wong, Melissa; Zhang, Lushuang; Webber, Chelsea Joy; Kilci, Alper; Jenkins, Matthew; Sun, Guangxin; Rashad, Sherif; Sun, Jingjing; Dedon, Peter C; Daley, Sarah Anne; Xia, Weiming; Ortiz, Alejandro Rondón; Dorrian, Luke; Saito, Takashi; Saido, Takaomi C; Wolozin, Benjamin

Accumulation of m⁶A exhibits stronger correlation with MAPT than ß-amyloid pathology in an APP^NL-G-F /MAPT^P301S mouse model of Alzheimer's disease.

Jiang, Lulu; Roberts, Rebecca; Wong, Melissa; Zhang, Lushuang; Webber, Chelsea Joy; Kilci, Alper; Jenkins, Matthew; Sun, Guangxin; Rashad, Sherif; Sun, Jingjing; Dedon, Peter C; Daley, Sarah Anne; Xia, Weiming; Ortiz, Alejandro Rondón; Dorrian, Luke; Saito, Takashi; Saido, Takaomi C; Wolozin, Benjamin.

Afiliación

Jiang L; Department of Pharmacology, Physiology and Biophysics, Chobanian and Avedesian School of Medicine, Boston University, Boston, MA, 02118.
Roberts R; Department of Pharmacology, Physiology and Biophysics, Chobanian and Avedesian School of Medicine, Boston University, Boston, MA, 02118.
Wong M; Department of Pharmacology, Physiology and Biophysics, Chobanian and Avedesian School of Medicine, Boston University, Boston, MA, 02118.
Zhang L; Department of Pharmacology, Physiology and Biophysics, Chobanian and Avedesian School of Medicine, Boston University, Boston, MA, 02118.
Webber CJ; Department of Pharmacology, Physiology and Biophysics, Chobanian and Avedesian School of Medicine, Boston University, Boston, MA, 02118.
Kilci A; Department of Pharmacology, Physiology and Biophysics, Chobanian and Avedesian School of Medicine, Boston University, Boston, MA, 02118.
Jenkins M; Department of Pharmacology, Physiology and Biophysics, Chobanian and Avedesian School of Medicine, Boston University, Boston, MA, 02118.
Sun G; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Rashad S; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Sun J; Department of Neurosurgical Engineering and Translational Neuroscience, Graduate School of Biomedical Engineering, Tohoku University, Sendai, Japan.
Dedon PC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Daley SA; Singapore-MIT Alliance for Research and Technology, Antimicrobial Resistance IRG, Campus for Research Excellence and Technological Enterprise, Singapore 138602, Singapore.
Xia W; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Ortiz AR; Singapore-MIT Alliance for Research and Technology, Antimicrobial Resistance IRG, Campus for Research Excellence and Technological Enterprise, Singapore 138602, Singapore.
Dorrian L; Department of Pharmacology, Physiology and Biophysics, Chobanian and Avedesian School of Medicine, Boston University, Boston, MA, 02118.
Saito T; Geriatric Research Education and Clinical Center, Bedford VA Healthcare System, Bedford, MA, 01730, USA.
Saido TC; Department of Pharmacology, Physiology and Biophysics, Chobanian and Avedesian School of Medicine, Boston University, Boston, MA, 02118.
Wolozin B; Geriatric Research Education and Clinical Center, Bedford VA Healthcare System, Bedford, MA, 01730, USA.

bioRxiv ; 2023 Mar 28.

Article en En | MEDLINE | ID: mdl-37034774

Palabras clave

Neurodegeneration; RNA binding proteins; RNA metabolism; RNA methylation; TIA1; Tauopathy; neuritic plaques; neuropathology; stress granules; tau fibrils; tau oligomers

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