Associations of Serum Antimicrobial Peptide LL-37 with Longitudinal Cognitive Decline and Neurodegeneration Among Older Adults with Memory Complaints.
J Alzheimers Dis
; 93(2): 595-603, 2023.
Article
en En
| MEDLINE
| ID: mdl-37066916
ABSTRACT
BACKGROUND:
A potential role of the antimicrobial peptide LL-37, which is upregulated after infection, in the pathogenesis of Alzheimer's disease (AD) was identified. However, the clinical relevance of LL-37 in AD is not clear yet.OBJECTIVE:
This study aims to investigate the association of circulating LL-37 with longitudinal cognitive decline and neurodegeneration among older adults with memory complaints.METHODS:
This cohort study recruited 357 older adults with memory complaints. Participants were followed-up for two years and the cognitive functions were assessed using the Mini-Mental State Examination (MMSE). Serum LL-37, pTau181, and tTau levels were determined at baseline. Associations of baseline LL-37 with longitudinal cognitive decline and change of neurodegenerative biomarkers were analyzed.RESULTS:
No difference was found in the slope of longitudinal cognitive decline during follow-up between the low and high LL-37 group, adjusting for age, sex, education, body mass index, APOE É4 carrier status, comorbidities, and baseline MMSE scores (difference in slope 0.226, 95% CI -0.169 to 0.621). Higher LL-37 levels were associated with longitudinal cognitive decline, as indicated by a decrease of MMSE scores of 3 points or above during follow-up (ORâ=â2.11, 95% CI 1.32 to 3.38). The high LL-37 group had larger slopes of the increase in neurofilament light (difference in slope 3.759, 95% CI 2.367 to 5.152) and pTau181 (difference in slope 0.325, 95% CI 0.151 to 0.499) than the low LL-37 group.CONCLUSION:
These findings support an association of the antimicrobial peptide LL-37 with AD from a clinical perspective.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de Alzheimer
/
Disfunción Cognitiva
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Humans
Idioma:
En
Revista:
J Alzheimers Dis
Asunto de la revista:
GERIATRIA
/
NEUROLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
China