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The Influence of Diabetes Mellitus on Mortality of Patients After Lower Extremity Amputation: A Systematic Review and Meta-analysis.
Yang, Dong; Shu, Hongxin; Lun, Yu; Li, Cong; Yang, Yu.
Afiliación
  • Yang D; Department of Vascular and Thyroid Surgery, The First Affiliated Hospital, China Medical University, No. 155, Nanjing North Street, Heping District, Shenyang, 110001, People's Republic of China.
  • Shu H; The Second Clinical Medical School, Nanchang University, Nanchang, 330006, Jiangxi, People's Republic of China.
  • Lun Y; Department of Vascular and Thyroid Surgery, The First Affiliated Hospital, China Medical University, No. 155, Nanjing North Street, Heping District, Shenyang, 110001, People's Republic of China.
  • Li C; Department of Vascular and Thyroid Surgery, The First Affiliated Hospital, China Medical University, No. 155, Nanjing North Street, Heping District, Shenyang, 110001, People's Republic of China.
  • Yang Y; Department of Vascular and Thyroid Surgery, The First Affiliated Hospital, China Medical University, No. 155, Nanjing North Street, Heping District, Shenyang, 110001, People's Republic of China. xgjzxyy@163.com.
World J Surg ; 47(8): 2076-2084, 2023 Aug.
Article en En | MEDLINE | ID: mdl-37084108
ABSTRACT

OBJECTIVE:

The influence of diabetes mellitus (DM) on mortality following lower extremity amputation (LEA) remains controversial. This systematic review and meta-analysis aimed to determine the influence of DM on long-term mortality (LTM) and short-term mortality (STM) after amputation. MATERIALS AND

METHODS:

The Medline, the Cochrane library, and Embase databases were searched. The primary and secondary outcomes were LTM and STM following amputation. One-year and 30-day all-cause mortality after amputation were considered as LTM and STM, respectively. A random-effects model was utilized to pool results. To evaluate the stability of results, subgroup analyses and sensitivity analyses were conducted.

RESULTS:

Twenty-three cohort studies with a total of 58,219 patients were included, among which 31,750 (54.5%) patients had DM. The mean score of included studies evaluated by Newcastle-Ottawa Scale was 7.65, indicating moderate to high quality. The pooled results showed no significant difference in 1-year LTM (risk ratio [RR], 0.96; 95% CI 0.86-1.07) after amputation. However, 3-year (RR, 1.22; 95% CI 1.01-1.47) and 5-year (RR, 1.18; 95% CI 1.07-1.31) LTMs of DM patients were obviously higher than that of NDM (non-diabetes mellitus) patients. The STM of the DM group was significantly lower than the NDM group (RR, 0.80; 95% CI 0.64-0.98).

CONCLUSIONS:

The current study revealed that DM patients had an obvious lower STM following LEA, but the risk of DM on LTM after amputation was gradually increased with time. More attention should be paid to the long-term survival of DM patients after LEA.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: World J Surg Año: 2023 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: World J Surg Año: 2023 Tipo del documento: Article