Persistent Degradation of HER2 Protein by Hybrid nanoPROTAC for Programmed Cell Death.

Wang, Zhihang; Tan, Mixiao; Su, Wen; Huang, Wenping; Zhang, Jie; Jia, Fuhao; Cao, Guoliang; Liu, Xinyang; Song, Haohao; Ran, Haitao; Nie, Guangjun; Wang, Hai

Wang, Zhihang; Tan, Mixiao; Su, Wen; Huang, Wenping; Zhang, Jie; Jia, Fuhao; Cao, Guoliang; Liu, Xinyang; Song, Haohao; Ran, Haitao; Nie, Guangjun; Wang, Hai.

Afiliación

Wang Z; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.
Tan M; University of Chinese Academy of Sciences, Beijing 100049, China.
Su W; The Second Affiliated Hospital of Chongqing Medical University & Chongqing Key Laboratory of Ultrasound Molecular Imaging, Chongqing 400010, China.
Huang W; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.
Zhang J; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.
Jia F; University of Chinese Academy of Sciences, Beijing 100049, China.
Cao G; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.
Liu X; University of Chinese Academy of Sciences, Beijing 100049, China.
Song H; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.
Ran H; University of Chinese Academy of Sciences, Beijing 100049, China.
Nie G; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.
Wang H; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.

J Med Chem ; 66(9): 6263-6273, 2023 05 11.

Article en En | MEDLINE | ID: mdl-37092695

Asunto(s)

Apoptosis; Proteínas; Humanos; Proteínas/metabolismo; Proteolisis; Ubiquitina-Proteína Ligasas/metabolismo; Quimera Dirigida a la Proteólisis

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas / Apoptosis Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: China

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