Targeted Deletion of Rictor in BMSCs Reduces the Biological Activity of K7M2 Cells and Mitigates OS-Induced Bone Destruction.

Lu, Jinhong; Dai, Dongfang; Zhang, Jiacheng; Wang, Rong; Miao, Dengshun; Sun, Weiwei

Lu, Jinhong; Dai, Dongfang; Zhang, Jiacheng; Wang, Rong; Miao, Dengshun; Sun, Weiwei.

Afiliación

Lu J; Department of Anatomy, Nanjing Medical University, Nanjing, People's Republic of China.
Dai D; Department of Radiotherapy, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing, People's Republic of China.
Zhang J; Department of Anatomy, Nanjing Medical University, Nanjing, People's Republic of China.
Wang R; Department of Anatomy, Nanjing Medical University, Nanjing, People's Republic of China.
Miao D; Department of Anatomy, Nanjing Medical University, Nanjing, People's Republic of China.
Sun W; The Research Center for Aging, Affiliated Friendship Plastic Surgery Hospital of Nanjing Medical University, Nanjing, People's Republic of China.

Stem Cells ; 41(6): 672-683, 2023 06 15.

Article en En | MEDLINE | ID: mdl-37099695

Asunto(s)

Neoplasias Óseas; Células Madre Mesenquimatosas; Osteosarcoma; Ratones; Animales; Osteogénesis; Células Madre Mesenquimatosas/metabolismo; Diferenciación Celular; Células de la Médula Ósea; Diana Mecanicista del Complejo 2 de la Rapamicina/metabolismo; Citocinas/metabolismo; Neoplasias Óseas/genética; Neoplasias Óseas/metabolismo; Células Cultivadas; Osteosarcoma/metabolismo; Microambiente Tumoral

Palabras clave

K7M2 cells; bone destruction; bone marrow mesenchymal stem cells; mTORC2 signaling; osteosarcoma

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Óseas / Osteosarcoma / Células Madre Mesenquimatosas Límite: Animals Idioma: En Revista: Stem Cells Año: 2023 Tipo del documento: Article

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