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An update on inflammation in uveal melanoma.
Liau, Sebastian; Wang, Janney Z; Zagarella, Ethan; Paulus, Paus; Dang, Nguyen Huong Que Hiep; Rawling, Tristan; Murray, Michael; Zhou, Fanfan.
Afiliación
  • Liau S; Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
  • Wang JZ; Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
  • Zagarella E; Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
  • Paulus P; Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
  • Dang NHQH; Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
  • Rawling T; School of Mathematical and Physical Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW, 2007, Australia.
  • Murray M; Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
  • Zhou F; Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. Electronic address: fanfan.zhou@sydney.edu.au.
Biochimie ; 212: 114-122, 2023 Sep.
Article en En | MEDLINE | ID: mdl-37105300
Uveal melanoma (UM) is the primary ocular cancer with upto 50% of patients dying from metastasis. Although rare, it is deadly as patients with metastatic UM seldom survive beyond 18 months after diagnosis. Chemotherapeutics have no proven efficacy, including immunotherapies that have been tried as current treatment options but produce marginal improvement in overall survival for UM patients. While therapeutics are low in efficacy, there is an urgent need to explore novel targets in the treatment of UM. This review provides an update on the contribution of inflammation to UM with a focus on exploring potential therapeutic targets related to the inflammatory tumour microenvironment. As a tumour promoting event, inflammation is one of the hallmarks of cancers. The presence of the inflammatory phenotype characterised by the abundance of immune mediators and proinflammatory cytokines surrounding UM tumours, is a potential area to explore novel therapeutic targets. Despite decades of investigation regarding the role UM tumour microenvironment has played, that of inflammation in UM progression remains poorly understood. With advancement of technologies, an understanding of the prognosis of UM has been accelerated. Excitingly, novel therapeutic targets related to the inflammatory tumour microenvironment have been identified and relevant studies are underway in their preliminary phases, illustrating optimistic results.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Úvea / Melanoma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Biochimie Año: 2023 Tipo del documento: Article País de afiliación: Australia

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Úvea / Melanoma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Biochimie Año: 2023 Tipo del documento: Article País de afiliación: Australia