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Less is more: Antibiotics at the beginning of life.
Stocker, Martin; Klingenberg, Claus; Navér, Lars; Nordberg, Viveka; Berardi, Alberto; El Helou, Salhab; Fusch, Gerhard; Bliss, Joseph M; Lehnick, Dirk; Dimopoulou, Varvara; Guerina, Nicholas; Seliga-Siwecka, Joanna; Maton, Pierre; Lagae, Donatienne; Mari, Judit; Janota, Jan; Agyeman, Philipp K A; Pfister, Riccardo; Latorre, Giuseppe; Maffei, Gianfranco; Laforgia, Nichola; Mózes, Eniko; Størdal, Ketil; Strunk, Tobias; Giannoni, Eric.
Afiliación
  • Stocker M; Department of Pediatrics, Children's Hospital Lucerne, Lucerne, Switzerland. martin.stocker@luks.ch.
  • Klingenberg C; Paediatric Research Group, Faculty of Health Sciences, UiT-The Arctic University of Norway, Tromsø, Norway.
  • Navér L; Dept. of Pediatrics and Adolescence Medicine, University Hospital of North Norway, Tromsø, Norway.
  • Nordberg V; Department of Neonatology, Karolinska University Hospital, Stockholm, Sweden.
  • Berardi A; Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.
  • El Helou S; Department of Neonatology, Karolinska University Hospital, Stockholm, Sweden.
  • Fusch G; Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.
  • Bliss JM; Neonatal Intensive Care Unit, Mother and Child Department, Policlinico University Hospital, Modena, Italy.
  • Lehnick D; Division of Neonatology, Department of Pediatrics, McMaster Children's Hospital, McMaster University, Hamilton Health Sciences, Hamilton, Canada.
  • Dimopoulou V; Division of Neonatology, Department of Pediatrics, McMaster Children's Hospital, McMaster University, Hamilton Health Sciences, Hamilton, Canada.
  • Guerina N; Department of Pediatrics, Women & Infants Hospital of Rhode Island, Warren Alpert Medical School of Brown University, Richmond, USA.
  • Seliga-Siwecka J; Biostatistics and Methodology, CTU-CS, Department of Health Sciences and Medicine, University of Lucerne, Luzern, Switzerland.
  • Maton P; Clinic of Neonatology, Department Mother-Woman-Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Lagae D; Department of Pediatrics, Women & Infants Hospital of Rhode Island, Warren Alpert Medical School of Brown University, Richmond, USA.
  • Mari J; Department of Neonatology and Neonatal Intensive Care, Medical University of Warsaw, Warszawa, Poland.
  • Janota J; Service néonatal, Clinique CHC-Montlegia, groupe santé CHC, Liège, Belgium.
  • Agyeman PKA; Neonatology and Neonatal Intensive Care Unit, CHIREC-Delta Hospital, Brussels, Belgium.
  • Pfister R; Department of Paediatrics, University of Szeged, Szeged, Hungary.
  • Latorre G; Neonatal Unit, Department of Obstetrics and Gynecology, Motol University Hospital Prague, Prague, Czech Republic.
  • Maffei G; Department of Neonatology, Thomayer University Hospital Prague, Prague, Czech Republic.
  • Laforgia N; Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Mózes E; Neonatology and Paediatric Intensive Care Unit, Geneva University Hospitals and Geneva University, Geneva, Switzerland.
  • Størdal K; Neonatology and Neonatal Intensive Care Unit, Ecclesiastical General Hospital F. Miulli, Acquaviva delle Fonti, Italy.
  • Strunk T; Neonatology and Neonatal Intensive Care Unit, Policlinico Riuniti Foggia, Foggia, Italy.
  • Giannoni E; Neonatologia e Terapia Intensiva Neonatale, University of Bari, Bari, Italy.
Nat Commun ; 14(1): 2423, 2023 04 27.
Article en En | MEDLINE | ID: mdl-37105958
Antibiotic exposure at the beginning of life can lead to increased antimicrobial resistance and perturbations of the developing microbiome. Early-life microbiome disruption increases the risks of developing chronic diseases later in life. Fear of missing evolving neonatal sepsis is the key driver for antibiotic overtreatment early in life. Bias (a systemic deviation towards overtreatment) and noise (a random scatter) affect the decision-making process. In this perspective, we advocate for a factual approach quantifying the burden of treatment in relation to the burden of disease balancing antimicrobial stewardship and effective sepsis management.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Sepsis / Sepsis Neonatal / Programas de Optimización del Uso de los Antimicrobianos Límite: Humans / Newborn Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Suiza
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Sepsis / Sepsis Neonatal / Programas de Optimización del Uso de los Antimicrobianos Límite: Humans / Newborn Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Suiza