Less is more: Antibiotics at the beginning of life.
Nat Commun
; 14(1): 2423, 2023 04 27.
Article
en En
| MEDLINE
| ID: mdl-37105958
Antibiotic exposure at the beginning of life can lead to increased antimicrobial resistance and perturbations of the developing microbiome. Early-life microbiome disruption increases the risks of developing chronic diseases later in life. Fear of missing evolving neonatal sepsis is the key driver for antibiotic overtreatment early in life. Bias (a systemic deviation towards overtreatment) and noise (a random scatter) affect the decision-making process. In this perspective, we advocate for a factual approach quantifying the burden of treatment in relation to the burden of disease balancing antimicrobial stewardship and effective sepsis management.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Sepsis
/
Sepsis Neonatal
/
Programas de Optimización del Uso de los Antimicrobianos
Límite:
Humans
/
Newborn
Idioma:
En
Revista:
Nat Commun
Asunto de la revista:
BIOLOGIA
/
CIENCIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Suiza