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Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPß levels in cerebrospinal fluid and 2D/3D cell culture models.
Wittrahm, Rebekka; Takalo, Mari; Kuulasmaa, Teemu; Mäkinen, Petra M; Mäkinen, Petri; Koncarevic, Sasa; Fartzdinov, Vadim; Selzer, Stefan; Kokkola, Tarja; Antikainen, Leila; Martiskainen, Henna; Kemppainen, Susanna; Marttinen, Mikael; Jeskanen, Heli; Rostalski, Hannah; Rahunen, Eija; Kivipelto, Miia; Ngandu, Tiia; Natunen, Teemu; Lambert, Jean-Charles; Tanzi, Rudolph E; Kim, Doo Yeon; Rauramaa, Tuomas; Herukka, Sanna-Kaisa; Soininen, Hilkka; Laakso, Markku; Pike, Ian; Leinonen, Ville; Haapasalo, Annakaisa; Hiltunen, Mikko.
Afiliación
  • Wittrahm R; Institute of Biomedicine, University of Eastern Finland, 70211 Kuopio, Finland. Electronic address: rebekka.wittrahm@uef.fi.
  • Takalo M; Institute of Biomedicine, University of Eastern Finland, 70211 Kuopio, Finland. Electronic address: mari.takalo@uef.fi.
  • Kuulasmaa T; Institute of Biomedicine, University of Eastern Finland, 70211 Kuopio, Finland. Electronic address: teemu.kuulasmaa@uef.fi.
  • Mäkinen PM; Institute of Biomedicine, University of Eastern Finland, 70211 Kuopio, Finland. Electronic address: petra.makinen@uef.fi.
  • Mäkinen P; A.I. Virtanen Institute for Molecular Sciences, 70211 Kuopio, Finland. Electronic address: petri.makinen@uef.fi.
  • Koncarevic S; Proteome Sciences GmbH & Co. KG, 60438 Frankfurt, Germany. Electronic address: sasa.koncarevic@proteomics.com.
  • Fartzdinov V; Proteome Sciences GmbH & Co. KG, 60438 Frankfurt, Germany.
  • Selzer S; Proteome Sciences GmbH & Co. KG, 60438 Frankfurt, Germany. Electronic address: stefan.selzer@proteomics.com.
  • Kokkola T; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, 70210 Kuopio, Finland. Electronic address: tarja.kokkola@uef.fi.
  • Antikainen L; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, 70210 Kuopio, Finland. Electronic address: leila.antikainen@uef.fi.
  • Martiskainen H; Institute of Biomedicine, University of Eastern Finland, 70211 Kuopio, Finland. Electronic address: henna.martiskainen@uef.fi.
  • Kemppainen S; Institute of Biomedicine, University of Eastern Finland, 70211 Kuopio, Finland. Electronic address: susanna.kemppainen@uef.fi.
  • Marttinen M; Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland; Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany. Electronic address: mikael.marttinen@tuni.fi.
  • Jeskanen H; Institute of Biomedicine, University of Eastern Finland, 70211 Kuopio, Finland. Electronic address: heli.jeskanen@uef.fi.
  • Rostalski H; A.I. Virtanen Institute for Molecular Sciences, 70211 Kuopio, Finland. Electronic address: hannah.rostalski@uef.fi.
  • Rahunen E; Institute of Biomedicine, University of Eastern Finland, 70211 Kuopio, Finland. Electronic address: eija.rahunen@uef.fi.
  • Kivipelto M; Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland; Division of Clinical Geriatrics, Department of Neurobiology, Center for Alzheimer Research, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; The Ageing Epidemiology Research Unit, School of Publi
  • Ngandu T; Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland; Division of Clinical Geriatrics, Department of Neurobiology, Center for Alzheimer Research, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
  • Natunen T; Institute of Biomedicine, University of Eastern Finland, 70211 Kuopio, Finland. Electronic address: teemu.natunen@uef.fi.
  • Lambert JC; U1167, University of Lille, Inserm, Institut Pasteur de Lille, F-59000 Lille, France. Electronic address: jean-charles.lambert@pasteur-lille.fr.
  • Tanzi RE; Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States. Electronic address: tanzi@helix.mgh.harvard.edu.
  • Kim DY; Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States. Electronic address: dkim@helix.mgh.harvard.edu.
  • Rauramaa T; Department of Pathology, Kuopio University Hospital, 70211 Kuopio, Finland; Unit of Pathology, Institute of Clinical Medicine, University of Eastern Finland, 70210 Kuopio, Finland. Electronic address: tuomas.rauramaa@kuh.fi.
  • Herukka SK; Department of Neurology, University of Eastern Finland, 70210 Kuopio, Finland; NeuroCenter, Neurology, Kuopio University Hospital, Kuopio, Finland. Electronic address: sanna-kaisa.herukka@uef.fi.
  • Soininen H; Department of Neurology, University of Eastern Finland, 70210 Kuopio, Finland. Electronic address: hilkka.soininen@uef.fi.
  • Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, 70210 Kuopio, Finland; Department of Medicine, Kuopio University Hospital, 70210 Kuopio, Finland. Electronic address: markku.laakso@uef.fi.
  • Pike I; Proteome Sciences plc, Hamilton House, London, WC1H 9BB, UK. Electronic address: ian.pike@proteomics.com.
  • Leinonen V; Department of Neurosurgery, Kuopio University Hospital, and Institute of Clinical Medicine, Unit of Neurosurgery, University of Eastern Finland, Kuopio, Finland. Electronic address: ville.leinonen@kuh.fi.
  • Haapasalo A; A.I. Virtanen Institute for Molecular Sciences, 70211 Kuopio, Finland. Electronic address: annakaisa.haapasalo@uef.fi.
  • Hiltunen M; Institute of Biomedicine, University of Eastern Finland, 70211 Kuopio, Finland. Electronic address: mikko.hiltunen@uef.fi.
Neurobiol Dis ; 182: 106140, 2023 06 15.
Article en En | MEDLINE | ID: mdl-37120095
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Precursor de Proteína beta-Amiloide / Enfermedad de Alzheimer Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Neurobiol Dis Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Precursor de Proteína beta-Amiloide / Enfermedad de Alzheimer Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Neurobiol Dis Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article