Nitrilase mediated mild hydrolysis of a carbon-14 nitrile for the radiosynthesis of 4-(7-hydroxycarbamoyl-[1-<sup>14</sup> C-heptanoyl]-oxy)-benzoic acid methyl ester, [<sup>14</sup> C]-SHP-141: A novel class I/II histone deacetylase (HDAC) inhibitor.

Kitson, Sean L; Watters, William; Moody, Thomas S; Chappell, Todd; Mazitschek, Ralph

Nitrilase mediated mild hydrolysis of a carbon-14 nitrile for the radiosynthesis of 4-(7-hydroxycarbamoyl-[1-¹⁴ C-heptanoyl]-oxy)-benzoic acid methyl ester, [¹⁴ C]-SHP-141: A novel class I/II histone deacetylase (HDAC) inhibitor.

Kitson, Sean L; Watters, William; Moody, Thomas S; Chappell, Todd; Mazitschek, Ralph.

Afiliación

Kitson SL; Department of Technology, Almac, 20 Seagoe Industrial Estate, Craigavon, UK.
Watters W; Department of Technology, Almac, 20 Seagoe Industrial Estate, Craigavon, UK.
Moody TS; Department of Technology, Almac, 20 Seagoe Industrial Estate, Craigavon, UK.
Chappell T; Arran Chemical Company Limited, Unit 1 Monksland Industrial Estate, Athlone, Co, Roscommon, Ireland.
Mazitschek R; Shape Pharmaceuticals Inc, Cambridge, MA, USA.

J Labelled Comp Radiopharm ; 66(7-8): 172-179, 2023 06.

Article en En | MEDLINE | ID: mdl-37186406

Asunto(s)

Ácido Benzoico; Inhibidores de Histona Desacetilasas; Inhibidores de Histona Desacetilasas/farmacología; Radioisótopos de Carbono; Ésteres; Nitrilos; Hidrólisis; Ácidos Hidroxámicos; Radiofármacos; Histona Desacetilasas

Palabras clave

[14C]-SHP-141; carbon-14 cyanation; histone deacetylase; hydroxamic acid; nitrilase; remetinostat

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ácido Benzoico / Inhibidores de Histona Desacetilasas Idioma: En Revista: J Labelled Comp Radiopharm Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google