Clinical significance of Notch pathway-associated microRNA-107 in pancreatic ductal adenocarcinoma.
Future Oncol
; 19(14): 1003-1012, 2023 May.
Article
en En
| MEDLINE
| ID: mdl-37199277
ABSTRACT
Background & aim:
MicroRNAs associated with the Notch pathway play a critical role in the progression of pancreatic carcinoma. Our aim was to study the clinical significance of miR-107 and NOTCH2 in pancreatic ductal adenocarcinoma (PDAC).Methods:
The circulating miR-107 levels in PDAC and controls were determined by qPCR. NOTCH2 protein (target) expression in tissue of PDAC, periampullary carcinoma, chronic pancreatitis and normal pancreatic tissue was assessed by immunohistochemistry.Results:
The circulating miR-107 levels were found to be significantly reduced in PDAC as compared with controls. Additionally, NOTCH2 protein expression was higher in PDAC tissue as compared with controls and was clinically associated with metastasis.Conclusion:
Our findings demonstrate the utility of circulating miR-107 as a potential differentiating marker in PDAC.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Pancreáticas
/
Carcinoma Ductal Pancreático
/
MicroARNs
Tipo de estudio:
Risk_factors_studies
/
Screening_studies
Límite:
Humans
Idioma:
En
Revista:
Future Oncol
Año:
2023
Tipo del documento:
Article
País de afiliación:
India