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Pregabalin attenuates long-lasting post-inflammatory nociplastic mechanical sensitization in mice.
Yajima, Manami; Takahashi, Yukari; Sugimura, Yae K; Kato, Fusao.
Afiliación
  • Yajima M; Center for Neuroscience of Pain and Department of Neuroscience, The Jikei University School of Medicine, Tokyo, Japan.
  • Takahashi Y; Department of Dental Anesthesiology, School of Dental Medicine, Tsurumi University, Yokohama, Japan.
  • Sugimura YK; Center for Neuroscience of Pain and Department of Neuroscience, The Jikei University School of Medicine, Tokyo, Japan.
  • Kato F; Center for Neuroscience of Pain and Department of Neuroscience, The Jikei University School of Medicine, Tokyo, Japan.
Neurobiol Pain ; 13: 100131, 2023.
Article en En | MEDLINE | ID: mdl-37215502
ABSTRACT
Nociplastic pain, the most recently proposed mechanistic descriptor of chronic pain, is the pain resulting from an altered nociceptive system and network without clear evidence of nociceptor activation, injury or disease in the somatosensory system. As the pain-associated symptoms in many patients suffering from undiagnosed pain would result from the nociplastic mechanisms, it is an urgent issue to develop pharmaceutical therapies that would mitigate the aberrant nociception in nociplastic pain. We have recently reported that a single injection of formalin to the upper lip shows sustained sensitization lasting for more than 12 days at the bilateral hindpaws, where there is no injury or neuropathy in rats. Using the equivalent model in mice, we show that pregabalin (PGB), a drug used for treating neuropathic pain, significantly attenuates this formalin-induced widespread sensitization at the bilateral hindpaws, even on the 6 day after the initial single orofacial injection of formalin. On the 10th day after formalin injection, the hindlimb sensitization before PGB injection was no more significant in mice receiving daily PGB injections, unlike those receiving daily vehicle injections. This result suggests that PGB would act on the central pain mechanisms that undergo nociplastic changes triggered by initial inflammation and mitigate widespread sensitization resulting from the established changes.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Neurobiol Pain Año: 2023 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Neurobiol Pain Año: 2023 Tipo del documento: Article País de afiliación: Japón