Continuous glucose monitoring parameters in pregnancy-related complications in patients with type 1 diabetes: a retrospective cohort study.
Pol Arch Intern Med
; 133(11)2023 11 29.
Article
en En
| MEDLINE
| ID: mdl-37227218
ABSTRACT
INTRODUCTION:
Continuous glucose monitoring (CGM) improves pregnancy outcomes in patients with type 1 diabetes (T1D).OBJECTIVES:
The primary study objective was to analyze associations between numerous novel CGM parameters and neonatal complications, such as largeforgestationalage (LGA) neonates, hypoglycemia, hyperbilirubinemia, transient breathing disorders, preterm births, as well as preeclampsia. PATIENTS ANDMETHODS:
In this singlecenter retrospective cohort study, we recruited 102 eligible pregnant women with T1D who were treated with sensoraugmented pumps with suspendbeforelow function from the first trimester. The pregnant patients were admitted for at least 1 control hospital visit in each trimester of gestation for anthropometric and laboratory measurements and collection of sensor data.RESULTS:
The median (interquartile range) percentage values for glycated hemoglobin (HbA1c) (first trimester, 6.23 [5.91-6.9]; second trimester, 5.49 [5.16-5.9]; third trimester, 5.75 [5.39-6.29]) and for timeinrange (first trimester, 72.4 [67.3-80.3]; second trimester, 72.5 [64.7-79.6]; third trimester, 75.9 [67.1-81.4] met the criteria of wellcontrolled T1D in each trimester of pregnancy. Nonetheless, we noted 27% of LGA births, 25% of neonatal hypoglycemia, 33% of hyperbilirubinemia, and 13% of preterm births. Worse glycemic control and more glycemic fluctuations in the second and third trimesters were mainly associated with increased risk of LGA at birth, transient breathing disorders, and hyperbilirubinemia.CONCLUSIONS:
CGM parameters (mean of daily differences, high blood glucose index, glycemic risk assessment in diabetes equation, or continuous overall net glycemic action) in the patients with T1D are significantly associated with the increased risk of LGA at birth and neonatal transient breathing disorders and hyperbilirubinemia. However, we did not find evidence that novel CGM indices could be more effective in predicting those events than the commonly used CGM parameters or HbA1c levels.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Complicaciones del Embarazo
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Embarazo en Diabéticas
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Nacimiento Prematuro
/
Diabetes Mellitus Tipo 1
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Hipoglucemia
Tipo de estudio:
Etiology_studies
/
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
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Newborn
/
Pregnancy
Idioma:
En
Revista:
Pol Arch Intern Med
Año:
2023
Tipo del documento:
Article
País de afiliación:
Polonia