Immunohistochemical expression of cAMP in fluoroedeniteinduced malignant pleural mesothelioma: Preliminary results.
Mol Med Rep
; 28(1)2023 Jul.
Article
en En
| MEDLINE
| ID: mdl-37232345
Despite advances in understanding of the biology of malignant pleural mesothelioma (MPM), the prognosis of this malignancy remains poor. Although asbestos still remains the main pathogenic agent of MPM, other asbestoslike fibers such as fluoroedenite (FE) fibers, induce MPM. Notable incidence and mortality rates of MPM have been found in Biancavilla, Italy, where FE fibers have been extracted from building materials for >50 years. Cyclic adenosine monophosphate (cAMP) is a secondary messenger that plays a key role in several physiological and pathological mechanisms regulating protein kinase A (PKA) and the CREB pathway. Hyperactivation of the cAMP/PKA/CREB pathway is involved in many neoplastic processes, including tumor cell proliferation, invasion and metastatic spread. The present study investigated immunohistochemical expression of cAMP in patients with FEinduced MPM, which included six males and four females with an age range of 5093 years. There was high immunoexpression of cAMP in 5 out of 10 tumors while the remaining 5 cases showed low immunoexpression. In addition, there was a correlation between cAMP overexpression and decreased survival times (mean overall survival times, 7.5 months in high expression group vs. 18 months in low expression group).
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Amianto
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Mesotelioma Maligno
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Neoplasias Pulmonares
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Mesotelioma
Límite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Mol Med Rep
Año:
2023
Tipo del documento:
Article
País de afiliación:
Italia