Your browser doesn't support javascript.
loading
Immunohistochemical expression of cAMP in fluoroedenite­induced malignant pleural mesothelioma: Preliminary results.
Broggi, Giuseppe; Filetti, Veronica; Magro, Gaetano; Morante, Brunella; Garro, Rossella; Ledda, Caterina; Rapisarda, Venerando; Lombardo, Claudia; Loreto, Carla; Caltabiano, Rosario.
Afiliación
  • Broggi G; Department of Medical, Surgical Sciences and Advanced Technologies G.F. Ingrassia, Anatomic Pathology, University of Catania, I­95123 Catania, Italy.
  • Filetti V; Human Anatomy and Histology Division, Department of Biomedical and Biotechnology Sciences, University of Catania, I­95123 Catania, Italy.
  • Magro G; Department of Medical, Surgical Sciences and Advanced Technologies G.F. Ingrassia, Anatomic Pathology, University of Catania, I­95123 Catania, Italy.
  • Morante B; Department of Medical, Surgical Sciences and Advanced Technologies G.F. Ingrassia, Anatomic Pathology, University of Catania, I­95123 Catania, Italy.
  • Garro R; Department of Medical, Surgical Sciences and Advanced Technologies G.F. Ingrassia, Anatomic Pathology, University of Catania, I­95123 Catania, Italy.
  • Ledda C; Occupational Medicine Division, Department of Clinical and Experimental Medicine, University of Catania, I­95123 Catania, Italy.
  • Rapisarda V; Occupational Medicine Division, Department of Clinical and Experimental Medicine, University of Catania, I­95123 Catania, Italy.
  • Lombardo C; Human Anatomy and Histology Division, Department of Biomedical and Biotechnology Sciences, University of Catania, I­95123 Catania, Italy.
  • Loreto C; Human Anatomy and Histology Division, Department of Biomedical and Biotechnology Sciences, University of Catania, I­95123 Catania, Italy.
  • Caltabiano R; Department of Medical, Surgical Sciences and Advanced Technologies G.F. Ingrassia, Anatomic Pathology, University of Catania, I­95123 Catania, Italy.
Mol Med Rep ; 28(1)2023 Jul.
Article en En | MEDLINE | ID: mdl-37232345
Despite advances in understanding of the biology of malignant pleural mesothelioma (MPM), the prognosis of this malignancy remains poor. Although asbestos still remains the main pathogenic agent of MPM, other asbestos­like fibers such as fluoro­edenite (FE) fibers, induce MPM. Notable incidence and mortality rates of MPM have been found in Biancavilla, Italy, where FE fibers have been extracted from building materials for >50 years. Cyclic adenosine monophosphate (cAMP) is a secondary messenger that plays a key role in several physiological and pathological mechanisms regulating protein kinase A (PKA) and the CREB pathway. Hyperactivation of the cAMP/PKA/CREB pathway is involved in many neoplastic processes, including tumor cell proliferation, invasion and metastatic spread. The present study investigated immunohistochemical expression of cAMP in patients with FE­induced MPM, which included six males and four females with an age range of 50­93 years. There was high immunoexpression of cAMP in 5 out of 10 tumors while the remaining 5 cases showed low immunoexpression. In addition, there was a correlation between cAMP overexpression and decreased survival times (mean overall survival times, 7.5 months in high expression group vs. 18 months in low expression group).
Asunto(s)
Palabras clave

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Amianto / Mesotelioma Maligno / Neoplasias Pulmonares / Mesotelioma Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Mol Med Rep Año: 2023 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Amianto / Mesotelioma Maligno / Neoplasias Pulmonares / Mesotelioma Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Mol Med Rep Año: 2023 Tipo del documento: Article País de afiliación: Italia