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Discovery of NXT-10796, an orally active, intestinally restricted EP4 agonist prodrug for the treatment of inflammatory bowel disease.
St-Onge, Miguel; Chefson, Amandine; Wu, Joyce; Caron-Duval, Édouard; Dumais, Valerie; Dorich, Stephane; Cox, Jennifer; Caron, Alex; Burch, Jason; Percival, M David; Therien, Alex G; Fader, Lee D.
Afiliación
  • St-Onge M; Inception Sciences Canada Inc., 7150 rue Frederick-Banting, Saint-Laurent, Quebec H4S 2A1, Canada.
  • Chefson A; Inception Sciences Canada Inc., 7150 rue Frederick-Banting, Saint-Laurent, Quebec H4S 2A1, Canada.
  • Wu J; Inception Sciences Canada Inc., 210- 887 Great Northern Way, Vancouver, British Columbia V5T4T5, Canada.
  • Caron-Duval É; Inception Sciences Canada Inc., 7150 rue Frederick-Banting, Saint-Laurent, Quebec H4S 2A1, Canada.
  • Dumais V; Inception Sciences Canada Inc., 7150 rue Frederick-Banting, Saint-Laurent, Quebec H4S 2A1, Canada.
  • Dorich S; Inception Sciences Canada Inc., 7150 rue Frederick-Banting, Saint-Laurent, Quebec H4S 2A1, Canada.
  • Cox J; Inception Sciences Canada Inc., 210- 887 Great Northern Way, Vancouver, British Columbia V5T4T5, Canada.
  • Caron A; Inception Sciences Canada Inc., 7150 rue Frederick-Banting, Saint-Laurent, Quebec H4S 2A1, Canada.
  • Burch J; Inception Sciences Canada Inc., 7150 rue Frederick-Banting, Saint-Laurent, Quebec H4S 2A1, Canada.
  • Percival MD; Inception Sciences Canada Inc., 210- 887 Great Northern Way, Vancouver, British Columbia V5T4T5, Canada.
  • Therien AG; Inception Sciences Canada Inc., 7150 rue Frederick-Banting, Saint-Laurent, Quebec H4S 2A1, Canada.
  • Fader LD; Inception Sciences Canada Inc., 7150 rue Frederick-Banting, Saint-Laurent, Quebec H4S 2A1, Canada. Electronic address: lfader@congruencetx.com.
Bioorg Med Chem Lett ; 91: 129351, 2023 07 15.
Article en En | MEDLINE | ID: mdl-37270073
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Profármacos / Enfermedades Inflamatorias del Intestino Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Profármacos / Enfermedades Inflamatorias del Intestino Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Canadá