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Helicobacter pylori attachment-blocking antibodies protect against duodenal ulcer disease.
Bugaytsova, Jeanna A; Moonens, Kristof; Piddubnyi, Artem; Schmidt, Alexej; Edlund, Johan Olofsson; Lisiutin, Gennadii; Brännström, Kristoffer; Chernov, Yevgen A; Thorel, Kaisa; Tkachenko, Iryna; Sharova, Oleksandra; Vikhrova, Iryna; Butsyk, Anna; Shubin, Pavlo; Chyzhma, Ruslana; Johansson, Daniel X; Marcotte, Harold; Sjöström, Rolf; Shevtsova, Anna; Bylund, Göran; Rakhimova, Lena; Lundquist, Anders; Berhilevych, Oleksandra; Kasianchuk, Victoria; Loboda, Andrii; Ivanytsia, Volodymyr; Hultenby, Kjell; Persson, Mats A A; Gomes, Joana; Matos, Rita; Gartner, Fátima; Reis, Celso A; Whitmire, Jeannette M; Merrell, D Scott; Pan-Hammarström, Qiang; Landström, Maréne; Oscarson, Stefan; D'Elios, Mario M; Agreus, Lars; Ronkainen, Jukka; Aro, Pertti; Engstrand, Lars; Graham, David Y; Kachkovska, Vladyslava; Mukhopadhyay, Asish; Chaudhuri, Sujit; Karmakar, Bipul Chandra; Paul, Sangita; Kravets, Oleksandr; Camorlinga, Margarita.
Afiliación
  • Bugaytsova JA; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.
  • Moonens K; SUMEYA, The Ukrainian-Swedish Research Center, Sumy State University, 40022 Sumy, Ukraine.
  • Piddubnyi A; Structural and Molecular Microbiology, VIB Department of Structural Biology, VIB, 1050 Brussels, Belgium.
  • Schmidt A; Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
  • Edlund JO; Present address: Ablynx, a Sanofi Company, Technologiepark 21, 9052 Zwijnaarde, Belgium.
  • Lisiutin G; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.
  • Brännström K; SUMEYA, The Ukrainian-Swedish Research Center, Sumy State University, 40022 Sumy, Ukraine.
  • Chernov YA; Department of Pathology, Medical Institute, Sumy State University, 40007 Sumy, Ukraine.
  • Thorel K; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.
  • Tkachenko I; Division of Clinical Immunology and Transfusion Medicine, Karolinska Institutet at Karolinska University Hospital, SE14186 Huddinge, Sweden.
  • Sharova O; Present address: Department of Medical Biosciences, Umeå University, SE90185 Umeå, Sweden.
  • Vikhrova I; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.
  • Butsyk A; The Biochemical Imaging Center Umeå (BICU), Umeå University, SE90187 Umeå, Sweden.
  • Shubin P; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.
  • Chyzhma R; Department of Microbiology, Virology and Biotechnology, Odesa Mechnikov National University, 65082 Odesa, Ukraine.
  • Johansson DX; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.
  • Marcotte H; The Biochemical Imaging Center Umeå (BICU), Umeå University, SE90187 Umeå, Sweden.
  • Sjöström R; Present address: Pfizer Worldwide R&D, BioMedicine Design, 10 555 Science Center Drive, San Diego CA, 92121 USA.
  • Shevtsova A; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.
  • Bylund G; Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Rakhimova L; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.
  • Lundquist A; Department of Public Health, Medical Institute, Sumy State University, 40007 Sumy, Ukraine.
  • Berhilevych O; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.
  • Kasianchuk V; Department of Pediatrics, Medical Institute, Sumy State University, 40018 Sumy, Ukraine.
  • Loboda A; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.
  • Ivanytsia V; Department of Pediatrics, Medical Institute, Sumy State University, 40018 Sumy, Ukraine.
  • Hultenby K; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.
  • Persson MAA; Department of Public Health, Medical Institute, Sumy State University, 40007 Sumy, Ukraine.
  • Gomes J; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.
  • Matos R; Department of Public Health, Medical Institute, Sumy State University, 40007 Sumy, Ukraine.
  • Gartner F; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.
  • Reis CA; SUMEYA, The Ukrainian-Swedish Research Center, Sumy State University, 40022 Sumy, Ukraine.
  • Whitmire JM; Department of Pathology, Medical Institute, Sumy State University, 40007 Sumy, Ukraine.
  • Merrell DS; Department of Clinical Neuroscience, Karolinska Institutet at Center for Molecular Medicine, Karolinska University Hospital, Solna, SE17176 Stockholm, Sweden.
  • Pan-Hammarström Q; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.
  • Landström M; Division of Clinical Immunology and Transfusion Medicine, Karolinska Institutet at Karolinska University Hospital, SE14186 Huddinge, Sweden.
  • Oscarson S; Department of Biosciences and Nutrition, Karolinska Institutet, SE14183, Huddinge, Sweden.
  • D'Elios MM; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.
  • Agreus L; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.
  • Ronkainen J; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.
  • Aro P; Department of Medical Biochemistry and Biophysics, Umeå University, SE90187 Umeå, Sweden.
  • Engstrand L; Present address: Department of Odontology, Umeå University, SE90187 Umeå, Sweden.
  • Graham DY; Department of Statistics, USBE, Umeå University, SE90187 Umeå, Sweden.
  • Kachkovska V; Umeå Center for Functional Brain Imaging, Umeå University, SE90187 Umeå, Sweden.
  • Mukhopadhyay A; Department of Public Health, Medical Institute, Sumy State University, 40007 Sumy, Ukraine.
  • Chaudhuri S; Department of Public Health, Medical Institute, Sumy State University, 40007 Sumy, Ukraine.
  • Karmakar BC; Department of Pediatrics, Medical Institute, Sumy State University, 40018 Sumy, Ukraine.
  • Paul S; Department of Microbiology, Virology and Biotechnology, Odesa Mechnikov National University, 65082 Odesa, Ukraine.
  • Kravets O; Departments of Laboratory Medicine, Division of Biomolecular and Cellular Medicine, Karolinska Institutet at Karolinska University Hospital, SE14186 Huddinge, Sweden.
  • Camorlinga M; Department of Clinical Neuroscience, Karolinska Institutet at Center for Molecular Medicine, Karolinska University Hospital, Solna, SE17176 Stockholm, Sweden.
bioRxiv ; 2023 May 24.
Article en En | MEDLINE | ID: mdl-37292721
The majority of the world population carry the gastric pathogen Helicobacter pylori. Fortunately, most individuals experience only low-grade or no symptoms, but in many cases the chronic inflammatory infection develops into severe gastric disease, including duodenal ulcer disease and gastric cancer. Here we report on a protective mechanism where H. pylori attachment and accompanying chronic mucosal inflammation can be reduced by antibodies that are present in a vast majority of H. pylori carriers. These antibodies block binding of the H. pylori attachment protein BabA by mimicking BabA's binding to the ABO blood group glycans in the gastric mucosa. However, many individuals demonstrate low titers of BabA blocking antibodies, which is associated with an increased risk for duodenal ulceration, suggesting a role for these antibodies in preventing gastric disease.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2023 Tipo del documento: Article País de afiliación: Suecia

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2023 Tipo del documento: Article País de afiliación: Suecia