The Râ³ wave in V1 and the negative terminal QRS vector in aVF combine to a novel 12-lead ECG algorithm to identify slow conducting anatomical isthmus 3 in patients with tetralogy of Fallot.
Europace
; 25(6)2023 06 02.
Article
en En
| MEDLINE
| ID: mdl-37314194
ABSTRACT
AIMS:
Patients with repaired tetralogy of Fallot (rTOF) have an increased risk of ventricular tachycardia (VT), with slow conducting anatomical isthmus (SCAI) 3 as dominant VT substrate. In patients with right bundle branch block (RBBB), SCAI 3 leads to local activation delay with a shift of terminal RV activation towards the lateral RV outflow tract which may be detected by terminal QRS vector changes on sinus rhythm electrocardiogram (ECG). METHODS ANDRESULTS:
Consecutive rTOF patients aged ≥16 years with RBBB who underwent electroanatomical mapping at our institution between 2017-2022 and 2010-2016 comprised the derivation and validation cohort, respectively. Forty-six patients were included in the derivation cohort (aged 40±15 years, QRS duration 165±23â ms). Among patients with SCAI 3 (n = 31, 67%), 17 (55%) had an Râ³ in V1, 18 (58%) had a negative terminal QRS portion (NTP) ≥80â ms in aVF, and 12 (39%) had both ECG characteristics, compared to only 1 (7%), 1 (7%), and 0 patient without SCAI, respectively.Combining Râ³ in V1 and/or NTP ≥80â ms in aVF into a diagnostic algorithm resulted in a sensitivity of 74% and specificity of 87% in detecting SCAI 3. The inter-observer agreement for the diagnostic algorithm was 0.875. In the validation cohort [n = 33, 18 (55%) with SCAI 3], the diagnostic algorithm had a sensitivity of 83% and specificity of 80% for identifying SCAI 3.CONCLUSION:
A sinus rhythm ECG-based algorithm including Râ³ in V1 and/or NTP ≥80â ms in aVF can identify rTOF patients with a SCAI 3 and may contribute to non-invasive risk stratification for VT.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tetralogía de Fallot
/
Taquicardia Ventricular
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Europace
Asunto de la revista:
CARDIOLOGIA
/
FISIOLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Países Bajos