Understanding the Effect of Nucleation in Amorphous Solid Dispersions through Time-Temperature Transformation.

Lalge, Rahul; Kumar, N S Krishna; Suryanarayanan, Raj

Lalge, Rahul; Kumar, N S Krishna; Suryanarayanan, Raj.

Afiliación

Lalge R; Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 9-177 WDH, 308 Harvard Street S.E., Minneapolis, Minnesota 55455, United States.
Kumar NSK; Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 9-177 WDH, 308 Harvard Street S.E., Minneapolis, Minnesota 55455, United States.
Suryanarayanan R; Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 9-177 WDH, 308 Harvard Street S.E., Minneapolis, Minnesota 55455, United States.

Mol Pharm ; 20(8): 4196-4209, 2023 08 07.

Article en En | MEDLINE | ID: mdl-37358932

Asunto(s)

Polímeros; Povidona; Temperatura; Povidona/química; Polímeros/química; Cristalización; Transición de Fase; Solubilidad; Metilcelulosa/química; Estabilidad de Medicamentos

Palabras clave

amorphous solid dispersion; crystallization; drug−polymer interactions; hot-melt extrusion; hydroxypropyl methylcellulose acetate succinate (HPMCAS); nifedipine; nucleation; polyvinylpyrrolidone (PVP); time−temperature transformation

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Polímeros / Povidona Idioma: En Revista: Mol Pharm Asunto de la revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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