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H10Nx avian influenza viruses detected in wild birds in China pose potential threat to mammals.
Lv, Xinru; Tian, Jingman; Li, Xiang; Bai, Xiaoli; Li, Yi; Li, Minghui; An, Qing; Song, Xingdong; Xu, Yu; Sun, Heting; Peng, Peng; Qin, Siyuan; Zhao, Zhenliang; Qin, Rongxiu; Xu, Qiuzi; Qu, Fengyi; Wang, Meixi; Luo, Hua; Zhang, Zhen; Zeng, Xiangwei; Wang, Yajun; Hou, Zhijun; Zhou, Xiaoyu; Wang, Yulong; Li, Yanbing; Chai, Hongliang.
Afiliación
  • Lv X; College of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
  • Tian J; State Key Laboratory of Veterinary Biotechnology, Chinese Academy of Agricultural Sciences, Harbin Veterinary Research Institute, Harbin 150069, China.
  • Li X; College of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
  • Bai X; State Key Laboratory of Veterinary Biotechnology, Chinese Academy of Agricultural Sciences, Harbin Veterinary Research Institute, Harbin 150069, China.
  • Li Y; College of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
  • Li M; State Key Laboratory of Veterinary Biotechnology, Chinese Academy of Agricultural Sciences, Harbin Veterinary Research Institute, Harbin 150069, China.
  • An Q; College of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
  • Song X; College of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
  • Xu Y; Biological Disaster Control and Prevention Center, National Forestry and Grassland Administration, Shenyang 110034, China.
  • Sun H; Biological Disaster Control and Prevention Center, National Forestry and Grassland Administration, Shenyang 110034, China.
  • Peng P; Biological Disaster Control and Prevention Center, National Forestry and Grassland Administration, Shenyang 110034, China.
  • Qin S; Biological Disaster Control and Prevention Center, National Forestry and Grassland Administration, Shenyang 110034, China.
  • Zhao Z; College of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
  • Qin R; College of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
  • Xu Q; College of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
  • Qu F; College of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
  • Wang M; College of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
  • Luo H; College of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
  • Zhang Z; College of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
  • Zeng X; College of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
  • Wang Y; College of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
  • Hou Z; College of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
  • Zhou X; Siberian Tiger Park, Harbin 150028, China.
  • Wang Y; College of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
  • Li Y; State Key Laboratory of Veterinary Biotechnology, Chinese Academy of Agricultural Sciences, Harbin Veterinary Research Institute, Harbin 150069, China.
  • Chai H; College of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
One Health ; 16: 100515, 2023 Jun.
Article en En | MEDLINE | ID: mdl-37363234
ABSTRACT
H10 subtype avian influenza viruses (AIVs) have been isolated from wild and domestic avian species worldwide and have occasionally crossed the species barrier to mammalian hosts. Fatal human cases of H10N8 infections and the recent detection of human H10N3 infections have drawn widespread public attention. In this study, 25 H10Nx viruses were isolated from wild waterfowl in China during a long-term surveillance of AIVs. We conducted phylogenetic and phylogeographic studies of the hemagglutinin (HA) genes of global H10 viruses to determine the spatiotemporal patterns of spread and the roles of different hosts in viral transmission. We found the pattern of AIV transmission from wild birds to poultry to humans, and Anatidae have acted as the seeding population in the spread of the virus. Phylogenetic incongruence indicated complex reassortment events and our isolates were divided into eight genotypes (G1-8). We also found that the HA genes of the G8 viruses belonged to the North American lineage, indicating that intercontinental gene flow has occurred. Their receptor-binding specificity showed that the G1/4/5/6/7/8 viruses bind to both human-type α2,6-linked sialic acid receptors and avian-type α2,3-linked sialic acid receptors. Mouse studies indicated that the H10Nx isolates replicated efficiently in the respiratory system without preadaptation, but showed low pathogenicity in mice. The H10Nx isolates showed no (G2/4/7) or low pathogenicity (G1/3/5/6/8) in chickens, and the G6 and G8 viruses could be transmitted to chickens through direct contact. The asymptomatic shedding of these wild-bird-origin H10Nx isolates in chickens and their good adaptation in mice should increase the ease of their transmission to humans, and they therefore pose a threat to public health. Our findings demonstrate a further understanding of wild bird-origin H10 viruses and provide information for the continuous surveillance of H10 subtype viruses.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: One Health Año: 2023 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: One Health Año: 2023 Tipo del documento: Article País de afiliación: China