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High glucose-upregulated PD-L1 expression through RAS signaling-driven downregulation of PTRH1 leads to suppression of T cell cytotoxic function in tumor environment.
Gao, Chenggang; Chen, Jiaoshun; Bai, Jianwei; Zhang, Haoxiang; Tao, Yanyi; Wu, Shihong; Li, Hehe; Wu, Heshui; Shen, Qiang; Yin, Tao.
Afiliación
  • Gao C; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • Chen J; Sino-German Laboratory of Personalized Medicine for Pancreatic Cancer, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • Bai J; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • Zhang H; Sino-German Laboratory of Personalized Medicine for Pancreatic Cancer, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • Tao Y; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • Wu S; Sino-German Laboratory of Personalized Medicine for Pancreatic Cancer, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • Li H; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • Wu H; Sino-German Laboratory of Personalized Medicine for Pancreatic Cancer, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • Shen Q; Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • Yin T; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
J Transl Med ; 21(1): 461, 2023 07 11.
Article en En | MEDLINE | ID: mdl-37434177
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Diabetes Mellitus Experimental / Antígeno B7-H1 / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Transl Med Año: 2023 Tipo del documento: Article País de afiliación: China
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Diabetes Mellitus Experimental / Antígeno B7-H1 / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Transl Med Año: 2023 Tipo del documento: Article País de afiliación: China