Headache frequency and neck pain are associated with trapezius muscle T2 in tension-type headache among young adults.
J Headache Pain
; 24(1): 84, 2023 Jul 12.
Article
en En
| MEDLINE
| ID: mdl-37438700
ABSTRACT
BACKGROUND:
Tension-type headache (TTH) is the most prevalent primary headache disorder. Neck pain is commonly associated with primary headaches and the trigemino-cervical complex (TCC) refers to the convergence of trigeminal and cervical afferents onto neurons of the brainstem, thus conceptualizes the emergence of headache in relation to neck pain. However, no objective biomarkers exist for the myofascial involvement in primary headaches. This study aimed to investigate the involvement of the trapezius muscles in primary headache disorders by quantitative magnetic resonance imaging (MRI), and to explore associations between muscle T2 values and headache frequency and neck pain.METHODS:
This cohort study prospectively enrolled fifty participants (41 females, age range 20-31 years) 16 subjects with TTH only (TTH-), 12 with mixed-type TTH plus migraine (TTH+), and 22 healthy controls (HC). The participants completed fat-suppressed T2-prepared three-dimensional turbo spin-echo MRI, a headache diary (over 30 days prior to MRI), manual palpation (two weeks before MRI), and evaluation of neck pain (on the day of MRI). The bilateral trapezius muscles were manually segmented, followed by muscle T2 extraction. Associations between muscle T2 and the presence of neck pain as well as the number of days with headache (considering the 30 days prior to imaging using the headache calendar) were analyzed using regression models (adjusting for age, sex, and body mass index).RESULTS:
The TTH+ group demonstrated the highest muscle T2 values (right side 31.4 ± 1.2 ms, left side 31.4 ± 0.8 ms) as compared to the TTH- group or HC group (p < 0.001). Muscle T2 was significantly associated with the number of headache days (ß-coefficient 2.04, p = 0.04) and the presence of neck pain (odds ratio 2.26, p = 0.04). With muscle T2 as the predictor, the area under the curve for differentiating between HC and the TTH+ group was 0.82.CONCLUSIONS:
Increased T2 of trapezius muscles may represent an objective imaging biomarker for myofascial involvement in primary headache disorders, which could help to improve patient phenotyping and therapy evaluation. Pathophysiologically, the increased muscle T2 values could be interpreted as a surrogate of neurogenic inflammation and peripheral sensitization within myofascial tissues.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Cefalea de Tipo Tensional
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Músculos Superficiales de la Espalda
Tipo de estudio:
Etiology_studies
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Guideline
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
Idioma:
En
Revista:
J Headache Pain
Asunto de la revista:
MEDICINA INTERNA
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NEUROLOGIA
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PSICOFISIOLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Alemania