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Investigating Associations of Omega-3 Fatty Acids, Lung Function Decline, and Airway Obstruction.
Patchen, Bonnie K; Balte, Pallavi; Bartz, Traci M; Barr, R Graham; Fornage, Myriam; Graff, Mariaelisa; Jacobs, David R; Kalhan, Ravi; Lemaitre, Rozenn N; O'Connor, George; Psaty, Bruce; Seo, Jungkyun; Tsai, Michael Y; Wood, Alexis C; Xu, Hanfei; Zhang, Jingwen; Gharib, Sina A; Manichaikul, Ani; North, Kari; Steffen, Lyn M; Dupuis, Josée; Oelsner, Elizabeth; Hancock, Dana B; Cassano, Patricia A.
Afiliación
  • Patchen BK; Division of Nutritional Sciences, Cornell University, Ithaca, New York.
  • Balte P; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York.
  • Bartz TM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Systems and Population Health.
  • Barr RG; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York.
  • Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center, Houston, Texas.
  • Graff M; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina.
  • Jacobs DR; Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota.
  • Kalhan R; Departments of Medicine and Preventative Medicine, Northwestern Medicine, Chicago, Illinois.
  • Lemaitre RN; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Systems and Population Health.
  • O'Connor G; Pulmonary, Allergy, Sleep and Critical Care Medicine, Boston University School of Medicine, Boston, Massachusetts.
  • Psaty B; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Systems and Population Health.
  • Seo J; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina.
  • Tsai MY; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota.
  • Wood AC; U.S. Department of Agriculture/Agricultural Research Service Children Nutrition Research Center, Houston, Texas.
  • Xu H; Departments of Biostatistics and Epidemiology, Boston University School of Public Health, Boston, Massachusetts.
  • Zhang J; Departments of Biostatistics and Epidemiology, Boston University School of Public Health, Boston, Massachusetts.
  • Gharib SA; Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, Washington.
  • Manichaikul A; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia.
  • North K; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center, Houston, Texas.
  • Steffen LM; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina.
  • Dupuis J; U.S. Department of Agriculture/Agricultural Research Service Children Nutrition Research Center, Houston, Texas.
  • Oelsner E; Department of Epidemiology, Biostatistics and Occupational Health, School of Population and Global Health, McGill University, Montréal, Québec, Canada.
  • Hancock DB; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York.
  • Cassano PA; RTI International, Research Triangle Park, North Carolina; and.
Am J Respir Crit Care Med ; 208(8): 846-857, 2023 Oct 15.
Article en En | MEDLINE | ID: mdl-37470492
Rationale: Inflammation contributes to lung function decline and the development of chronic obstructive pulmonary disease. Omega-3 fatty acids have antiinflammatory properties and may benefit lung health. Objectives: To investigate associations of omega-3 fatty acids with lung function decline and incident airway obstruction in a diverse sample of adults from general-population cohorts. Methods: Complementary study designs: 1) longitudinal study of plasma phospholipid omega-3 fatty acids and repeated FEV1 and FVC measures in the NHLBI Pooled Cohorts Study and 2) two-sample Mendelian randomization (MR) study of genetically predicted omega-3 fatty acids and lung function parameters. Measurements and Main Results: The longitudinal study found that higher omega-3 fatty acid levels were associated with attenuated lung function decline in 15,063 participants, with the largest effect sizes for the most metabolically downstream omega-3 fatty acid, docosahexaenoic acid (DHA). An increase in DHA of 1% of total fatty acids was associated with attenuations of 1.4 ml/yr for FEV1 (95% confidence interval [CI], 1.1-1.8) and 2.0 ml/yr for FVC (95% CI, 1.6-2.4) and a 7% lower incidence of spirometry-defined airway obstruction (95% CI, 0.89-0.97). DHA associations persisted across sexes and smoking histories and in Black, White, and Hispanic participants, with associations of the largest magnitude in former smokers and Hispanic participants. The MR study showed similar trends toward positive associations of genetically predicted downstream omega-3 fatty acids with FEV1 and FVC. Conclusions: The longitudinal and MR studies provide evidence supporting beneficial effects of higher levels of downstream omega-3 fatty acids, especially DHA, on lung health.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ácidos Grasos Omega-3 / Enfermedad Pulmonar Obstructiva Crónica / Obstrucción de las Vías Aéreas Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: Am J Respir Crit Care Med Asunto de la revista: TERAPIA INTENSIVA Año: 2023 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ácidos Grasos Omega-3 / Enfermedad Pulmonar Obstructiva Crónica / Obstrucción de las Vías Aéreas Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: Am J Respir Crit Care Med Asunto de la revista: TERAPIA INTENSIVA Año: 2023 Tipo del documento: Article