Exploring the Epidemiology and Survival Trends in Pediatric Major Salivary Gland Malignancies: Insights from the National Cancer Database.
Curr Oncol
; 30(7): 6134-6147, 2023 06 25.
Article
en En
| MEDLINE
| ID: mdl-37504316
ABSTRACT
OBJECTIVE:
To investigate the clinicopathological, therapeutic, and survival data on pediatric major salivary gland cancers. MATERIALS ANDMETHODS:
National Cancer Database (NCDB) query from 2004 to 2018.RESULTS:
In total, 967 cases of individuals under the age of 21 were identified. Most cancers affected the parotid gland (86%). Mucoepidermoid carcinoma (41.3%) and acinic cell adenocarcinoma (33.6%) were the most common. Tumors occurred more often from age 11 to 21, and females were more affected. Histology varied by age, gender, and race. In the 0-5 age group, mucoepidermoid carcinoma and myoepithelial carcinoma/sarcoma/rhabdomyosarcoma were the most common pathologies. In patients over 5 years old, mucoepidermoid carcinoma was the most frequent tumor in boys, while acinic cell adenocarcinoma was more common in girls. African American patients had a higher incidence of mucoepidermoid carcinoma, while White patients in the 0-5 age group had a higher incidence of myoepithelial carcinoma/sarcoma/rhabdomyosarcoma tumors. Low-grade tumors were commonly diagnosed at stage I, but the 0-5 age group had a high frequency of stage IV tumors. The overall 5-year survival rate was 94.9%, with 90% for the 0-5 years age group and 96% for the 11-15 years age group. Negative margins were associated with higher 5-year survival rates in high-stage tumors (93%) compared to positive margins (80%). Submandibular malignancies had worse 5-year survival rates across all age groups.CONCLUSIONS:
Major salivary gland malignancies in pediatric patients exhibit variations in histopathologic characteristics by age, gender, and race. Negative margins impact 5-year survival rates, especially in high-stage tumors.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Rabdomiosarcoma
/
Sarcoma
/
Neoplasias de las Glándulas Salivales
/
Carcinoma
/
Carcinoma Mucoepidermoide
/
Carcinoma de Células Acinares
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Curr Oncol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos