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Pretreated EGFRdel19/BRAFV600E Lung Adenocarcinoma With Leptomeningeal Disease Achieving Long-Lasting Disease Control on Osimertinib, Dabrafenib, and Trametinib: A Case Report.
Orciuolo, Corrado; Cappuzzo, Federico; Landi, Lorenza; Resuli, Blerina; Carpano, Silvia; Vidiri, Antonello; Buglioni, Simonetta; Mandoj, Chiara; Ciliberto, Gennaro; Minuti, Gabriele.
Afiliación
  • Orciuolo C; Division of Medical Oncology 2, IRCCS National Cancer Institute Regina Elena, Rome, Italy.
  • Cappuzzo F; Division of Medical Oncology 2, IRCCS National Cancer Institute Regina Elena, Rome, Italy.
  • Landi L; Clinical Trials Center: Phase 1 and Precision Medicine, IRCCS National Cancer Institute Regina Elena, Rome, Italy.
  • Resuli B; Division of Medical Oncology 2, IRCCS National Cancer Institute Regina Elena, Rome, Italy.
  • Carpano S; Division of Medical Oncology 2, IRCCS National Cancer Institute Regina Elena, Rome, Italy.
  • Vidiri A; IRCCS Regina Elena National Cancer Institute, Rome, Italy.
  • Buglioni S; IRCCS Regina Elena National Cancer Institute, Rome, Italy.
  • Mandoj C; IRCCS Regina Elena National Cancer Institute, Rome, Italy.
  • Ciliberto G; IRCCS Regina Elena National Cancer Institute, Rome, Italy.
  • Minuti G; Clinical Trials Center: Phase 1 and Precision Medicine, IRCCS National Cancer Institute Regina Elena, Rome, Italy.
JTO Clin Res Rep ; 4(8): 100545, 2023 Aug.
Article en En | MEDLINE | ID: mdl-37533438
ABSTRACT
Oncogene-addicted NSCLC inevitably becomes resistant to targeted therapy by developing acquired resistance through on- or off-target mechanisms, potentially detectable by liquid biopsy. We present the first reported case of a patient with pretreated EGFRdel19/BRAFV600E lung adenocarcinoma and symptomatic leptomeningeal metastasis obtaining durable clinical benefit on osimertinib, dabrafenib, and trametinib treatment.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: JTO Clin Res Rep Año: 2023 Tipo del documento: Article País de afiliación: Italia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: JTO Clin Res Rep Año: 2023 Tipo del documento: Article País de afiliación: Italia