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Furan fatty acid extracted from Hevea brasiliensis latex increases muscle mass in mice.
Pelletier, François; Durand, Erwann; Chaiyut, Jatuporn; Bronstein, Clémence; Pessemesse, Laurence; Vaysse, Laurent; Liengprayoon, Siriluck; Gaillet, Sylvie; Brioche, Thomas; Bertrand-Gaday, Christelle; Coudray, Charles; Sultan, Ariane; Feillet-Coudray, Christine; Casas, François.
Afiliación
  • Pelletier F; DMEM, Univ Montpellier, INRAE, Montpellier, France.
  • Durand E; CIRAD, UMR Qualisud, 34398 Montpellier, France; Qualisud, Univ Montpellier, Avignon Université, CIRAD, Institut Agro, IRD, Université de La Réunion, Montpellier, France.
  • Chaiyut J; Kasetsart Agricultural and Agro-industrial Product Improvement Institute, Kasetsart University, Bangkok, Thaïland.
  • Bronstein C; DMEM, Univ Montpellier, INRAE, Montpellier, France.
  • Pessemesse L; DMEM, Univ Montpellier, INRAE, Montpellier, France.
  • Vaysse L; CIRAD, UPR BioWooEB, 34398 Montpellier, France; BioWooEB, Univ Montpellier, CIRAD, Montpellier, France.
  • Liengprayoon S; Kasetsart Agricultural and Agro-industrial Product Improvement Institute, Kasetsart University, Bangkok, Thaïland.
  • Gaillet S; DMEM, Univ Montpellier, INRAE, Montpellier, France.
  • Brioche T; DMEM, Univ Montpellier, INRAE, Montpellier, France.
  • Bertrand-Gaday C; DMEM, Univ Montpellier, INRAE, Montpellier, France.
  • Coudray C; DMEM, Univ Montpellier, INRAE, Montpellier, France.
  • Sultan A; Département d'Endocrinologie, Diabète, Nutrition Inserm 1411, CHU de Montpellier, Univ Montpellier, Montpellier, France.
  • Feillet-Coudray C; DMEM, Univ Montpellier, INRAE, Montpellier, France. Electronic address: christine.coudray@inrae.fr.
  • Casas F; DMEM, Univ Montpellier, INRAE, Montpellier, France. Electronic address: francois.casas@inrae.fr.
Biomed Pharmacother ; 166: 115330, 2023 Oct.
Article en En | MEDLINE | ID: mdl-37595430
Skeletal muscle is essential for locomotion and plays a crucial role in energy homeostasis. It is regulated by nutrition, genetic factors, physical activity and hormones. Furan fatty acids (FuFAs) are minor fatty acids present in small quantities in food from plants and animals origin. Recently, we showed that a preventive nutritional supplementation with furan fatty acid in a DIO mouse model reduces metabolic disorders. The present study was designed to determine the influence of FuFA-F2 extracted from Hevea brasiliensis latex on skeletal muscle phenotype. In C2C12 myotubes we found that FuFA-F2 whatever the concentration used increased protein content. We revealed that in C2C12 myotubes FuFA-F2 (10 µM) increases protein synthesis as shown by the stimulation of mTOR phosphorylation. Next, to confirm in vivo our results C57Bl6 mice were supplemented by oral gavage with vehicle or FuFA-F2 (20 mg/kg) for 3 and a half weeks. We found that mice supplemented with FuFA-F2 had a greater lean mass than the control mice. In line with this observation, we revealed that FuFA-F2 increased muscle mass and promoted more oxidative muscle metabolism in mice as attested by cytochrome c oxidase activity. In conclusion, we demonstrated that FuFA-F2 stimulates muscle anabolism in mice in vitro and in vivo, mimicking in part physical activity. This study highlights that in vivo FuFA-F2 may have health benefits by increasing muscle mass and oxidative metabolism.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Hevea Tipo de estudio: Prognostic_studies Límite: Animals País/Región como asunto: America do sul / Brasil Idioma: En Revista: Biomed Pharmacother Año: 2023 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Hevea Tipo de estudio: Prognostic_studies Límite: Animals País/Región como asunto: America do sul / Brasil Idioma: En Revista: Biomed Pharmacother Año: 2023 Tipo del documento: Article País de afiliación: Francia