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STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts.
Buckbinder, Leonard; St Jean, David J; Tieu, Trang; Ladd, Brendon; Hilbert, Brendan; Wang, Weixue; Alltucker, Jacob T; Manimala, Samantha; Kryukov, Gregory V; Brooijmans, Natasja; Dowdell, Gregory; Jonsson, Philip; Huff, Michael; Guzman-Perez, Angel; Jackson, Erica L; Goncalves, Marcus D; Stuart, Darrin D.
Afiliación
  • Buckbinder L; Research and Development, Scorpion Therapeutics, Boston, Massachusetts.
  • St Jean DJ; Research and Development, Scorpion Therapeutics, Boston, Massachusetts.
  • Tieu T; Research and Development, Scorpion Therapeutics, Boston, Massachusetts.
  • Ladd B; Research and Development, Scorpion Therapeutics, Boston, Massachusetts.
  • Hilbert B; Research and Development, Scorpion Therapeutics, Boston, Massachusetts.
  • Wang W; Research and Development, Scorpion Therapeutics, Boston, Massachusetts.
  • Alltucker JT; Research and Development, Scorpion Therapeutics, Boston, Massachusetts.
  • Manimala S; Research and Development, Scorpion Therapeutics, Boston, Massachusetts.
  • Kryukov GV; Research and Development, Scorpion Therapeutics, Boston, Massachusetts.
  • Brooijmans N; Research and Development, Scorpion Therapeutics, Boston, Massachusetts.
  • Dowdell G; Research and Development, Scorpion Therapeutics, Boston, Massachusetts.
  • Jonsson P; Research and Development, Scorpion Therapeutics, Boston, Massachusetts.
  • Huff M; Research and Development, Scorpion Therapeutics, Boston, Massachusetts.
  • Guzman-Perez A; Research and Development, Scorpion Therapeutics, Boston, Massachusetts.
  • Jackson EL; Department of Biology, Scorpion Therapeutics, South San Francisco, California.
  • Goncalves MD; Division of Endocrinology, Department of Medicine, Weill Cornell Medicine, New York, New York.
  • Stuart DD; Research and Development, Scorpion Therapeutics, Boston, Massachusetts.
Cancer Discov ; 13(11): 2432-2447, 2023 11 01.
Article en En | MEDLINE | ID: mdl-37623743
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Neoplasias Límite: Female / Humans Idioma: En Revista: Cancer Discov Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Neoplasias Límite: Female / Humans Idioma: En Revista: Cancer Discov Año: 2023 Tipo del documento: Article