The Potent and Selective Histamine H3 Receptor Antagonist E169 Counteracts Cognitive Deficits and Mitigates Disturbances in the PI3K/AKT/GSK-3ß Signaling Pathway in MK801-Induced Amnesia in Mice.

Abdalla, Sabna; Eissa, Nermin; Jayaprakash, Petrilla; Beiram, Rami; Kuder, Kamil J; Lazewska, Dorota; Kiec-Kononowicz, Katarzyna; Sadek, Bassem

Abdalla, Sabna; Eissa, Nermin; Jayaprakash, Petrilla; Beiram, Rami; Kuder, Kamil J; Lazewska, Dorota; Kiec-Kononowicz, Katarzyna; Sadek, Bassem.

Afiliación

Abdalla S; Department of Pharmacology & Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.
Eissa N; Zayed Bin Sultan Center for Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.
Jayaprakash P; Department of Biomedical Sciences, College of Health Sciences, Abu Dhabi University, Abu Dhabi P.O. Box 59911, United Arab Emirates.
Beiram R; Department of Pharmacology & Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.
Kuder KJ; Zayed Bin Sultan Center for Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.
Lazewska D; Department of Pharmacology & Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.
Kiec-Kononowicz K; Zayed Bin Sultan Center for Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.
Sadek B; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9 St., 30-688 Krakow, Poland.

Int J Mol Sci ; 24(16)2023 Aug 12.

Article en En | MEDLINE | ID: mdl-37628900

Asunto(s)

Enfermedad de Alzheimer; Antagonistas de los Receptores Histamínicos H3; Animales; Ratones; Ratones Endogámicos C57BL; Glucógeno Sintasa Quinasa 3 beta; Fosfatidilinositol 3-Quinasas; Maleato de Dizocilpina; Antagonistas de los Receptores Histamínicos H3/farmacología; Antagonistas de los Receptores Histamínicos H3/uso terapéutico; Proteínas Proto-Oncogénicas c-akt; Fosfatidilinositol 3-Quinasa; Serina-Treonina Quinasas TOR; Amnesia/inducido químicamente; Amnesia/tratamiento farmacológico; Enfermedad de Alzheimer/tratamiento farmacológico; Transducción de Señal; Cognición

Palabras clave

Alzheimer's disease; E169; MK801-induced amnesia; PI3K/AKT/GSK-3ß signaling pathway; antagonists; cognition; histamine H3 receptors; memory; mice; neurodegenerative diseases; neuroinflammation; novel object recognition test

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antagonistas de los Receptores Histamínicos H3 / Enfermedad de Alzheimer Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Emiratos Árabes Unidos

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